Protein Alignment OtopLc and Otop3

DIOPT Version :10

• Sequence 1: NP_001303575.1
• Gene: OtopLc / 7354434
• FlyBaseID: FBgn0259150
• Length: 1596
• Species: Drosophila melanogaster
• Sequence 2: NP_081408.2
• Gene: Otop3 / 69602
• MGIID: 1916852
• Length: 596
• Species: Mus musculus
• Alignment Length: 688
• Identity: 152/688 - (22%)
• Similarity: 255/688 - (37%)
• Gaps: 170/688 - (24%)

  Fly   825 PDSSDPPSSPGGSSSQPALSGSQADGQLALMYHSHQLTNYPVLPAIK---RTHRPSFVYPPMPRV 886
            |....|..||...:::.|.|..|||     |...|  ...|..|..|   ..|....:.......
Mouse     8 PAEPAPMPSPEAKTTEGASSYDQAD-----METKH--AGSPCPPKQKSWLARHFSLLLRRDRQAQ 65

  Fly   887 KAGDALATLFSALYGKLLVVMGIAFPMAEVISTYIPPSFYEVYYLYLYIGSMIFLLFMYATLIWG 951
            |||.    |||.|....:|.:|.|| :..:|...:..:..:|:.|...:..:..|..:|.|:
Mouse    66 KAGQ----LFSGLLALNVVFLGGAF-ICSMIFNKVSVTLGDVWILLAALKVLSLLWLLYYTV--- 122

  Fly   952 RPKLPVPIASPSKSATKASGTDSMDESDTDSNSVHHRLPPPIPVRRPSLLSPLGRRDAHYGSFYL 1016
                               ||                      .|:|..:.   .||.|.|..::
Mouse   123 -------------------GT----------------------TRKPHAVL---YRDPHAGPIWV 143

  Fly  1017 RMGAVAFGIGSMIYSGLEFGQYFELNPDTK---CHNVLLALTPATRMAFIFIQMYFIFLN-NEQI 1077
            |...|.||..::..:      .|.:..|..   |.:.:..:.||..:.|:.||.:.::.: .:.:
Mouse   144 RGSLVLFGSCTVCLN------IFRMGYDVSHIHCKSEVELIFPAIEIVFMIIQTWVLWRHCKDCV 202

  Fly  1078 KVYRYKIIARFGLMHMIGTNLAVWLNVLIQETKHEILTFYNPENRTLRISHRIPGHSRGHAIIQH 1142
            :|...  ..|.|||..:.|||.:|:..:..::.|.            .|...:.......:::|.
Mouse   203 QVQTN--FTRCGLMLTLATNLLMWVLAVTNDSMHR------------EIEAELDALMEKFSVLQC 253

  Fly  1143 DPTAH--LRVPRGLKG-PYQIFECRRTNII-----GTLVQDASPFLFPCTIEYSLICAAILYVMW 1199
            .....  |.:|..|.| ......|..|.:.     |.|:      |:|.:.||.|||.|:|:|||
Mouse   254 RTCLRCCLFLPYLLSGNGTNTCMCLNTTVCEVFRKGYLM------LYPFSTEYCLICCAVLFVMW 312

  Fly  1200 RSISRP-QTPTPQRPDMISSPMKRSPHHYSVDCARAHKGLF---VGILILVLTIISLIIFFVLIS 1260
            :::||. ...|...|:       |||.       |.|..:|   :|:|.||..:...::|.:..|
Mouse   313 KNVSRSLAAHTGAHPN-------RSPF-------RLHGTIFGPLLGLLALVAGVCVFVLFQIEAS 363

  Fly  1261 RPEFVAMAVTEVTICELLIYGTATIATLVGM----IQIRHLQYDAYRSFSLDDILLVGAQTGSFL 1321
            .|:......|......:.:..|.::|.|.|.    ::.|.|......:.|||.:||:||..|...
Mouse   364 GPDIARQYFTLYYAFYVAVLPTMSLACLAGTAIHGLEERELDTLKNPTRSLDVVLLMGAALGQMG 428

  Fly  1322 YNIFTVIA-----GHFTLRSDDMLVPINALASIVQTACQTMFILD-------------------- 1361
            ...|:::|     .|..|   :.|:...:|..|:|...|.:||::
Mouse   429 IAYFSIVAIVATQPHELL---NQLILAYSLLLILQHITQNLFIIEGLHRRPLWEPAVSGVMEKQD 490

  Fly  1362 ------------------ASRRQAVSPEHL--RKKPGREIVTFMLVVNLAMWAISTLEKSRAESH 1406
                              |||....|..||  :::..:||..|:::.|:.:|.:..........:
Mouse   491 VELPRRGSLRELGQDLRRASRAYIHSFSHLNWKRRMLKEISLFLILCNITLWMMPAFGIHPEFEN 555

  Fly  1407 PIQLNFYGLWAWTIITHVSMPLAIFYRFHSTVCLCEIW 1444
            .::.:|||...|..|.:..:||.:|||.||...|.|::
Mouse   556 GLEKDFYGYRTWFTIVNFGLPLGVFYRMHSVGGLVEVY 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLc	NP_001303575.1	Retinal	<442..643	CDD:464722
		Otopetrin	1015..1434	CDD:460840	107/483 (22%)
Otop3	NP_081408.2	Otopetrin	148..582	CDD:460840	105/476 (22%)