Protein Alignment OtopLc and otop2

DIOPT Version :10

• Sequence 1: NP_001303575.1
• Gene: OtopLc / 7354434
• FlyBaseID: FBgn0259150
• Length: 1596
• Species: Drosophila melanogaster
• Sequence 2: XP_001338079.4
• Gene: otop2 / 494472
• ZFINID: ZDB-GENE-050104-2
• Length: 572
• Species: Danio rerio
• Alignment Length: 700
• Identity: 146/700 - (20%)
• Similarity: 253/700 - (36%)
• Gaps: 224/700 - (32%)

  Fly   831 PSSPGGSSSQPALSGSQAD-----GQLA-LMYHSHQLTNYPVLPAIKRTHRPSFVYPPMPRVKAG 889
            |....||.|..:...::||     .|:: :...||..|             |:..:.|:.:.:..
Zfish     6 PQKASGSYSCSSNMSTKADLEAMENQISTIQISSHGET-------------PNRGFKPVEKGRNW 57

  Fly   890 DALATLFSALYGKLL---VVMGIAFPMAEVISTYIPPSFYEVYYLYLYIGSMIFLLF-------M 944
            ..|.:.|.:|...||   :|.|..|...::.|:::     .::.:.|.|.|.:::|:       :
Zfish    58 GWLLSGFISLNALLLGIAIVSGSVFNKVQITSSHL-----LIFLILLVILSTVWMLYYKVHTSRV 117

  Fly   945 YATLIWGRPKLPVPIASPSKSATKASGTDSMDESDTDSNSVHHRLPPPIPVRRPSLLSPLGRRDA 1009
            |..:::                                                        :|:
Zfish   118 YRAVLY--------------------------------------------------------KDS 126

  Fly  1010 HYGSFYLRMGAVAFGIGSMIYSGLEFGQYF-ELNPDTKCHNVLLALTPATRMAFIFIQMYFIFLN 1073
            |.|..:||.|.|.|||.|:|....:...|. .:|    |.:.:....|..:..|:.:|.|.::::
Zfish   127 HAGPVWLRTGLVLFGICSVIMDIFKIIFYVGRMN----CESPVKIAFPVVQAVFVIVQTYVLWIH 187

  Fly  1074 NE---QIKVYRYKIIARFGLMHMIGTNLAVWLNVLIQETKHEILTFYNPENRTLRISHRIPGHSR 1135
            .:   |||    :.|.|.|||..:.|||.||:..:.:|:.|:.:....|
Zfish   188 AKDCVQIK----QNITRCGLMLTLSTNLMVWMMAVTEESLHQTVAPVKP---------------- 232

  Fly  1136 GHAIIQHDPTAHLRVPRGLKGPYQIFECRRTNIIGTLVQDASPFLFPCTIEYSLICAAILYVMWR 1200
                    ||.:......|.|.....||...:.:..|.:.|..:|:|..|||||..:|:.||||:
Zfish   233 --------PTNNNSYNDTLDGRAAASECECLHNMCDLFEKAYYYLYPFNIEYSLFASAMTYVMWK 289

  Fly  1201 SISRPQTPTPQRPDMISSPMKRSPHHYSVDCARAHK----------GLFVGILILVLTIISLIIF 1255
            ::.|                |...||       :||          |...|:::||..:.:.:::
Zfish   290 NVGR----------------KMDDHH-------SHKLHFSLWDVLVGPLAGLIVLVAGLATFVVY 331

  Fly  1256 FVLIS------RPEFVAMAVTEVTICELLIYGTATIATLVGMIQIRHLQYDAYRSFSLDDILLVG 1314
            .|.:|      :.|.:.|......:..||:..:|....::..:..|........:.|||..||||
Zfish   332 EVDVSKDDPKKKEEALIMHYIMNIVAVLLMSSSALAGCILFRMDKREQVSGKNPTRSLDVGLLVG 396

  Fly  1315 AQTGSFLYNIFTVIA-------GHFTLRSDDMLVPIN---ALASIVQTACQTMFIL--------- 1360
            |..|.||...||::|       ||..        .:|   |:.::::...|..|::
Zfish   397 ASLGQFLICYFTIVAVLASGVQGHTN--------GLNLACAMLTVIELCIQNAFLIKGLHREPFK 453

  Fly  1361 -----------------DASRR-QAVSPEHLRKKP-----GR---------EIVTFMLVVNLAMW 1393
                             |..|| .::.|.|....|     ||         ||..|:|:.|:.:|
Zfish   454 ETEVATVFANVMAVKERDPERRSSSIVPAHTLPIPLTLLQGRMSWKRRVLKEICAFLLLCNVTLW 518

  Fly  1394 AISTLEKSRAESHPIQLNFYGLWAWTIITHVSMPLAIFYRFHSTVCLCEI 1443
            .|..........:.:..:.|....|..:.::.||..||||.||...|.|:
Zfish   519 IIPAFGARPQFDNTVGPDVYEFQTWAAVVNIGMPFGIFYRMHSVASLFEV 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLc	NP_001303575.1	Retinal	<442..643	CDD:464722
		Otopetrin	1015..1434	CDD:460840	112/489 (23%)
otop2	XP_001338079.4	Otopetrin	133..558	CDD:460840	111/487 (23%)