Protein Alignment OtopLc and Otop1

DIOPT Version :10

• Sequence 1: NP_001303575.1
• Gene: OtopLc / 7354434
• FlyBaseID: FBgn0259150
• Length: 1596
• Species: Drosophila melanogaster
• Sequence 2: NP_766297.2
• Gene: Otop1 / 21906
• MGIID: 2388363
• Length: 600
• Species: Mus musculus
• Alignment Length: 741
• Identity: 142/741 - (19%)
• Similarity: 259/741 - (34%)
• Gaps: 265/741 - (35%)

  Fly   823 GGPDSSDPPSSPGGS--SSQPALSGSQADGQLALMYHSHQLTNYPVLPAIKRTHRPSFVYPPMPR 885
            |||.:   ||||..|  ||:.|.||..|               .|:.|            ||:.|
Mouse     3 GGPGA---PSSPAASSGSSRAAPSGIAA---------------CPLSP------------PPLAR 37

  Fly   886 -----------VKAGDALATLFSALYGKLLVVMGIAFPMA-EVISTYIPPS----------FYEV 928
                       ......||...|:.||..:.|.|:.|.:| .|.:|.:..|          ..::
Mouse    38 GSPQASGPRRGASVPQKLAETLSSQYGLNVFVAGLLFLLAWAVHATGVGKSDLLCVLTALMLLQL 102

  Fly   929 YYLYLYIGSMIFLLFMYATLIWGRPKLPVPIASPSKSATKASGTDSMDESDTDSNSVHHRLPPPI 993
            .::..|:|..    :|...||  |||
Mouse   103 LWMLWYVGRS----YMQRRLI--RPK--------------------------------------- 122

  Fly   994 PVRRPSLLSPLGRRDAHYGSFYLRMGAVAFGIGSMIYSGLEFGQYFELNPDTKCHNVLLALTPAT 1058
                          |.|.|:.:||.....|...:::...|:...:...   ::|.:....:.|.|
Mouse   123 --------------DTHAGARWLRGSITLFAFITVVLGCLKVAYFIGF---SECLSATEGVFPVT 170

  Fly  1059 RMAFIFIQMYFIFLNNEQIKVYRYKIIARFGLMHMIGTNLAVWLNVLIQETKHEILTFYNPENRT 1123
            ......:|:||::.:.:.| :..:|.:.|||::|.:.|||.:|.|.::.|:||::   ...:.|.
Mouse   171 HAVHTLLQVYFLWGHAKDI-IMSFKTLERFGVIHSVFTNLLLWANSVLNESKHQL---NEHKERL 231

  Fly  1124 LRISHRIPGHSRGHAII---QHDPTAHLRVPRGLKGPYQIFECRRTNIIGTLVQDASPFLFPCTI 1185
            :.:..       |:..|   .|.|..:...|                .:.:.:.....:|:|..|
Mouse   232 ITLGF-------GNITIVLDDHTPQCNCTPP----------------ALCSALSHGIYYLYPFNI 273

  Fly  1186 EYSLICAAILYVMWRSISRPQTPTPQRPDMISSPMKRSPHHYSVDCARAHKGLFV----GILILV 1246
            ||.::.:.:|||:|::|.|       |.|        |..|..:.|  ...|:.|    |:.:|.
Mouse   274 EYQILASTMLYVLWKNIGR-------RVD--------SSQHQKMQC--RFDGVLVGSVLGLTVLA 321

  Fly  1247 LTIISLIIFFVLISRPE---------FVAMAVTEVTICELLIYGTA-TIATLVGMIQIRHLQYDA 1301
            .||..::::.:.|.|.:         |...|:|     .||:.|.| .:.:.:..:..:.|....
Mouse   322 ATIAVVVVYMIHIGRSKSKSESALIMFYLYAIT-----VLLLMGAAGLVGSWIYRVDEKSLDESK 381

  Fly  1302 YRSFSLDDILLVGAQTGSFLYNIFTVIA-------GHFTLRSDDMLVPINALASIVQTACQTMFI 1359
            ..:..||..|||...:||:|.:..:::|       ..:|..:    :|.:.|. ||:...|.:||
Mouse   382 NPARKLDVDLLVATGSGSWLLSWGSILAIACAETRPPYTWYN----LPYSVLV-IVEKYVQNIFI 441

  Fly  1360 LDASRRQAVS-PEHLR----------------------------------------KKPGRE--- 1380
            :::...:... ||.:|                                        ::.|:|
Mouse   442 IESVHLEPEGVPEDVRTLRVVTVCSSEAAALAASTLGSQGMAQDGSPAVNGNLCLQQRCGKEDQE 506

  Fly  1381 ---------------------------IVTFMLVVNLAMWAISTLEKSRAESHPIQLNFYGLWAW 1418
                                       |..|:.:.|:::|............:.::...:|...|
Mouse   507 SGWEGATGTTRCLDFLQGGMKRRLLRNITAFLFLCNISLWIPPAFGCRPEYDNGLEEIVFGFEPW 571

  Fly  1419 TIITHVSMPLAIFYRFHSTVCLCEIW 1444
            .|:.:::||.:||||.|:...|.|::
Mouse   572 IIVVNLAMPFSIFYRMHAAAALFEVY 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLc	NP_001303575.1	Retinal	<442..643	CDD:464722
		Otopetrin	1015..1434	CDD:460840	96/513 (19%)
Otop1	NP_766297.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		19/76 (25%)
		Otopetrin	131..586	CDD:460840	95/511 (19%)