Protein Alignment UBE3A and HUL4

DIOPT Version :10

• Sequence 1: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Sequence 2: NP_012570.3
• Gene: HUL4 / 853494
• SGDID: S000003797
• Length: 892
• Species: Saccharomyces cerevisiae
• Alignment Length: 826
• Identity: 223/826 - (26%)
• Similarity: 369/826 - (44%)
• Gaps: 186/826 - (22%)

Human   196 AACSAAAMEEDSE-----ASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETA 255
            :||....:.::.|     .||:.|..:.:|...:.:...||:.      |...|.:|..|:....
Yeast   103 SACQVTVIVKEPEINSNLESSTHISCTLEGLQMVVRRCHDDLQ------RLKKTGILDKERKGLI 161

Human   256 FLNALVYLSPNVECDLTYHNVYSRDPNYL------NL----------FIIVMENRNLHSPEYLEM 304
            |...:.||...      :|:|...:.::|      |:          |..::.|.....|.|
Yeast   162 FQPVITYLLDR------FHDVSILNRSFLVHDGGKNIKMLNYEVLQRFYSILSNLPTRKPYY--- 217

Human   305 ALPLFCKAMSKLPLAAQGKLIRL----W-------------------SK--YNADQIRRM----- 339
            ::...|..:.|.....:|:.:::    |                   ||  :...|||.:
Yeast   218 SMLCCCNDLLKRITINKGENLQILQYRWLLIILNIPTIRTCLIRDRKSKNVFETQQIRAVSYELA 282

Human   340 -----------METFQQLI-----------TYKV--------------ISNEFNSR---NLVNDD 365
                       .:|.||||           :|:|              :|||.::|   |.|..:
Yeast   283 KRCIGYLSNLSTKTSQQLIQSLRRTPTDNFSYQVEILNLYINFQFSRLLSNELSNRTAKNNVKPE 347

Human   366 D--------------------AIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQ 410
            |                    .|.|.|...:...:.:.|..::.....:.:::..|..:::||..
Yeast   348 DEMRSRLRRHHTTGHEFLSTRPISAQSNDKQGSGFTHPVNNKMKFKFFQYEEDWHIHSAAKLTFI 412

Human   411 ELLGEERRNKKGPRVDPLETELGVK-----TLDCRKPLIPFEEFINE--------PLNEVLEMDK 462
            ..:...|||.:|        .|.::     |||    .|.:::..:.        .:|:::|...
Yeast   413 YYVANTRRNGRG--------ALSIQSFYNITLD----FIDYKQDFDHWRGVAQKTKMNQLIEEWG 465

Human   463 DYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKV 527
            :.|     |:..|||...||||:...|...:.|:.|..|..|.....|.||.:|:.::.|.::||
Yeast   466 NST-----TKKCFSFCKYPFILSLGIKISIMEYEIRRIMEHEAEQAFLISLDKGKSVDVYFKIKV 525

Human   528 RRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTY 592
            |||.|..|:|..::    |:..||.|.|.:||..|.|:|.||:.||:|.|:.:.:|||..|:|.|
Yeast   526 RRDVISHDSLRCIK----EHQGDLLKSLRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPMNGLFIY 586

Human   593 DESTKLFWF--NPSSFE-TEGQ------FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTF 648
            .:.:...||  :|.:|: ::|:      :.|.|:|:||||:|:.|||:.||..:|:||..:..:|
Yeast   587 IKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSF 651

Human   649 RDLGDSHPVLYQSLKDLLEY-EGNVEDDMMITFQISQTDLFGNPMMYDLK-----------ENGD 701
            .|..:..|...::|..:|.| |.|.||...:||:.:..:  .|.::.|.|           |||.
Yeast   652 EDYSELFPETSRNLIKMLNYTEDNFEDVFSLTFETTYRN--NNWILNDSKSSKEYVTVELCENGR 714

Human   702 KIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSR--- 763
            .:|||..|:.|||..:.::.|.||:|.|:..|..||..|..|.....||..||:|.|:||..
Yeast   715 NVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQT 779

Human   764 NLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIA 828
            ..||::|...|:|.||::.||..:..||||:.|:....::..|||.|.:||.|..|:..:...|:
Yeast   780 KFDFKSLRSVTKYVGGFSDDSRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIPFKIS 844

Human   829 KNGP-DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFG 873
            ..|. |::.||.:|||||.:.|..||||:||:.:||.||..::|:|
Yeast   845 LLGSHDSDDLPLAHTCFNEICLWNYSSKKKLELKLLWAINESEGYG 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:465173
		HECTc	523..873	CDD:238033	138/374 (37%)
HUL4	NP_012570.3	HUL4	1..892	CDD:227354	223/826 (27%)