Protein Alignment UBE3A and ube3a

DIOPT Version :8

• Sequence 1: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Sequence 2: XP_012812141.1
• Gene: ube3a / 407881
• XenbaseID: XB-GENE-948557
• Length: 908
• Species: Xenopus tropicalis
• Alignment Length: 868
• Identity: 795/869 (91%)
• Similarity: 842/869 (97%)
• Gaps: 4/869 (0%)

Human    12 GEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELY 76
            |:|.|:::|.||||||||||||||||||||||||||.||||||||||||||||||||||||||||
 Frog    41 GDPYSENLENSRMKRAAAKHLIERYYHQLTEGCGNETCTNEFCASCPTFLRMDNNAAAIKALELY 105

Human    77 KINAKLCDPHPSKKGASSAYLE-NSKGAPNNSCSEIKMNKK---GARIDFKDVTYLTEEKVYEIL 137
            |:|||||||||||||.||:||| |||.|.||||:|.|||||   |.|.||||||:|:||||||||
 Frog   106 KVNAKLCDPHPSKKGTSSSYLENNSKSAHNNSCTERKMNKKDLHGPRDDFKDVTFLSEEKVYEIL 170

Human   138 ELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAA 202
            |||||:||||||||||||||||||||||||||.|.||||||||||.||||||||||||||.||||
 Frog   171 ELCREKEDYSPLIRVIGRVFSSAEALVQSFRKAKHHTKEELKSLQEKDEDKDEDEKEKAASSAAA 235

Human   203 MEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYLSPNV 267
            |||||.|||||:.|:||||||:|||||::||:||:|:||||.|||||||||||||||||||||||
 Frog   236 MEEDSGASSSRLSDNSQGDNNIQKLGPEEVSLDIEAVRRVYHRLLSNEKIETAFLNALVYLSPNV 300

Human   268 ECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYN 332
            ||||||||||||||||||||||||||.|||||||||||||||||||||||||||.|||||||||:
 Frog   301 ECDLTYHNVYSRDPNYLNLFIIVMENGNLHSPEYLEMALPLFCKAMSKLPLAAQAKLIRLWSKYS 365

Human   333 ADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDD 397
            |:|||||||||||||||||||||||||||||||||||||:||||||||:||||||::|:||||:|
 Frog   366 AEQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAATKCLKMVYYSNVVGGEIETDHNEEED 430

Human   398 EEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDK 462
            :||:||||||||||||||||||||||||||||||||||::||||||||||||:|||||:||||||
 Frog   431 DEPVPESSELTLQELLGEERRNKKGPRVDPLETELGVKSIDCRKPLIPFEEFVNEPLNDVLEMDK 495

Human   463 DYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKV 527
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   496 DYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKV 560

Human   528 RRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTY 592
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   561 RRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTY 625

Human   593 DESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPV 657
            |||||..||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||
 Frog   626 DESTKHSWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLADSHPV 690

Human   658 LYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYIL 722
            ||||||:|||||||||:|||:|||||||||||||:|:||||||||||||||||||||:||:||||
 Frog   691 LYQSLKELLEYEGNVEEDMMMTFQISQTDLFGNPLMHDLKENGDKIPITNENRKEFVSLYTDYIL 755

Human   723 NKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLI 787
            ||||||||||||||||||||||||||||||||||||||||||||||||::||||||||||||.:|
 Frog   756 NKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALKDTTEYDGGYTRDSNII 820

Human   788 REFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEY 852
            :||||||:|||:|||||||||||||||||||||||||||||||||||:|||||||||||||||||
 Frog   821 KEFWEIVNSFTEEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTDRLPTSHTCFNVLLLPEY 885

Human   853 SSKEKLKERLLKAITYAKGFGML 875
            |:|||||||||||||||||||||
 Frog   886 SNKEKLKERLLKAITYAKGFGML 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBE3A	NP_000453.2	AZUL	29..83	CDD:318707	52/54 (96%)
		HECTc	523..873	CDD:238033	331/350 (95%)
ube3a	XP_012812141.1	AZUL	58..112	CDD:293166	52/54 (96%)
		HECTc	556..906	CDD:238033	331/350 (95%)
		HECTc	583..905	CDD:214523	303/322 (94%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C366044202
eggNOG	1	0.900				E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000				H7988
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D276447at33208
OrthoFinder	1	1.000				FOG0007635
OrthoInspector	0	0.000	Not matched by this tool.
Phylome	1	0.910		0.667	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
	8	7.720