DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG9733

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_651784.2	Gene:	CG9733 / 43601	FlyBaseID:	FBgn0039759	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	416	Identity:	110/416 - (26%)
Similarity:	151/416 - (36%)	Gaps:	107/416 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   337 NLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDF 401
            |.||      |...|...||..|:...  .:|.......|.|....|:..:....:.|....|:.
  Fly    71 NNQP------YVCCTQDTGYVRIQRQD--RTFPDYGAFGGDWEEERPQSFVFPRQERRPWSFGNQ 127

Human   402 RYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCG 466
            ..|:               ..|:.|..|..||....|.                       |.||
  Fly   128 PATS---------------RTPFRKSSTSDGSSLLPQP-----------------------PSCG 154

Human   467 KPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGG--------GALLGDRWILTAAHTLYPKEH 523
                .|..|.||..||...:..|||.|......|.|        |:|:..|::|||||.|..: .
  Fly   155 ----GVGIRNRIYDGQDTDVNEFPWMVLLEYRRRSGNGLSTACAGSLINRRYVLTAAHCLTGR-I 214

Human   524 EAQSNASLDVFLG----HTNVE----------ELMKLGNHPIRRVSVHPDYRQDESYNFEGDIAL 574
            |.:....:.|.||    .|.|:          |:.:||...||   ||..|.:..| |...||.|
  Fly   215 EREVGTLVSVRLGEHDTRTAVDCPPGGGSCSPEVQRLGFEEIR---VHERYSEKAS-NQVHDIGL 275

Human   575 LELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPV--------ANP 631
            :.:|.:|....|:.|||||.:     :||....||...........|:..|..|        .:|
  Fly   276 IRMERNVRYSDNIQPICLPSS-----VGLESRQSGQQFTVAGWGRTLKMARSAVKQKVTVNYVDP 335

Human   632 QACENWLRGKNRMDVFSQNM----FCAGHPSLKQDACQGDSGG-VFAVRDPNTDRWVATGIVSWG 691
            ..|      :.|......|:    .||| ...::|:|.||||| :...||   :.||..||||:|
  Fly   336 AKC------RQRFSQIKVNLEPTQLCAG-GQFRKDSCDGDSGGPLMRFRD---ESWVLEGIVSFG 390

Human   692 IGCS-RGY-GFYTKVLNYVDWIKKEM 715
            ..|. :.: |.||.|..|..||::.:
  Fly   391 YKCGLKDWPGVYTNVAAYDIWIRQNV 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569	12/47 (26%)
		Sushi	390..461	CDD:306569	9/70 (13%)
		Tryp_SPc	477..711	CDD:214473	82/270 (30%)
CG9733	NP_651784.2	CLIP	25..78	CDD:288855	4/12 (33%)
		Tryp_SPc	161..412	CDD:214473	82/270 (30%)
		Tryp_SPc	162..415	CDD:238113	83/272 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910