DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG9737

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_651783.1	Gene:	CG9737 / 43600	FlyBaseID:	FBgn0039758	Length:	424	Species:	Drosophila melanogaster

Alignment Length:	432	Identity:	119/432 - (27%)
Similarity:	175/432 - (40%)	Gaps:	111/432 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   376 GTWHRAMPRCKI-KDCGQPRNLPNGDFRYTTTMGVNTYKARIQY--YCHEP------YYKMQTRA 431
            |.::|.:...:: ::|..|.....|     ..:.|:..||.:|.  ..:.|      ..|:|...
  Fly    13 GCFYRFLALAEVLQECDIPNETKRG-----VCLEVSRCKAYLQVRNATNLPAEKVNFLKKVQCEV 72

Human   432 GSRESE-QGVY----TCTAQG---------IWKNEQ----------KGEKIPR------------ 460
            ..:.|| ||.|    .|.|.|         ..|.|.          |.:|:.|
  Fly    73 EQQVSEAQGSYESLVCCPANGQDYLFPVLQFSKFEYRRFLDVTARFKRKKLKRRIQTVEPSSGFN 137

Human   461 CLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVF----TNIHGRGGGALLGDRWILTAAHTLYPK 521
            .|..|||.|.     .||.||:.|::..|||...    :|.:| ..|||:.||.||||||.:
  Fly   138 LLNECGKQVT-----NRIYGGEIAELDEFPWLALLVYNSNDYG-CSGALIDDRHILTAAHCV--- 193

Human   522 EHEAQSNASLD------VFLGHTNVE---ELMKLGNH----------PIRRVSVHPDYRQDESYN 567
                |.....|      |.||..||:   :.::..|:          ...::.|||:|::..:|.
  Fly   194 ----QGEGVRDRQGLKHVRLGEFNVKTEPDCIEEPNYLSCADAALDIAYEKIHVHPEYKEFSNYK 254

Human   568 FEGDIALLELENSVTLGPNLLPICLPDNDTFYDL--GLMGYVSGFGVME------EKIAHDLRF- 623
            : .|||::.|::.|:....::|||||:......|  |.|..|||:|..:      ..|...::.
  Fly   255 Y-NDIAIIRLKHPVSFTHFVMPICLPNKSEPLTLAEGQMFSVSGWGRTDLFNKYFINIHSPIKLK 318

Human   624 VRLPVANPQACENWLRGKN-RMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGI 687
            :|:|..:.:.|...|.|.. |:   .....|||....| |.|.|||||.....|....||||.|:
  Fly   319 LRIPYVSNENCTKILEGFGVRL---GPKQICAGGEFAK-DTCAGDSGGPLMYFDRQHSRWVAYGV 379

Human   688 VSWGI---GCSRGYGFYTKVLNYVDWI-------KKEMEEED 719
            ||:|.   |.:.....||.|..|.|||       ||..:.:|
  Fly   380 VSYGFTQCGMAGKPAVYTNVAEYTDWIDSVVQQRKKSQQTQD 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569	2/8 (25%)
		Sushi	390..461	CDD:306569	23/114 (20%)
		Tryp_SPc	477..711	CDD:214473	84/269 (31%)
CG9737	NP_651783.1	CLIP	28..89	CDD:288855	15/65 (23%)
		Tryp_SPc	149..406	CDD:214473	84/269 (31%)
		Tryp_SPc	150..409	CDD:238113	85/271 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910