DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG5909

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_651544.1	Gene:	CG5909 / 43274	FlyBaseID:	FBgn0039495	Length:	381	Species:	Drosophila melanogaster

Alignment Length:	384	Identity:	98/384 - (25%)
Similarity:	166/384 - (43%)	Gaps:	66/384 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   382 MPRCKI--KDCGQPRNLPNGDFRY------TTTMGVNTYKARIQYYCHEPYYKMQTRA------- 431
            :|:..|  ..|..|........||      ...:|:  |...|....|....:||.|:
  Fly    15 LPQLVISQSSCVTPAQAAGQCIRYQECPFVQKILGI--YGRNIPRKIHNQISEMQCRSTTNTRDF 77

Human   432 -----------GSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAK 485
                       .::||::.|.......:.:.:::|.::...:..||...||     ::.||:.|:
  Fly    78 HLCCPNEAPPQSNQESQRKVVRSEGGNLNRYDRQGLQLLNSVTNCGNKGNP-----KVSGGKTAR 137

Human   486 MGNFPWQVFTNIH------GRGGGALLGDRWILTAAHTLYPK---------EHEAQSNASLDVFL 535
            .|:|||.......      .|.||:|:.:|.||||||.:..:         ||:.:|..... :|
  Fly   138 PGDFPWVALLKYKINDPRPFRCGGSLISERHILTAAHCIIDQPEVIAVRLGEHDLESEEDCH-YL 201

Human   536 GHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYD 600
            |.||...:.....:.|.::.|||:|...:   ...|:|:::|:..|....::.|:|||.:....:
  Fly   202 GGTNRVCIPPYEEYGIEQIRVHPNYVHGK---ISHDVAIIKLDRVVKEKSHIKPVCLPIDQKSQE 263

Human   601 LGL--MGYVSGFGVME-EKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQD 662
            |..  ..:|:|:|..| |.:|..|:...:...:...|..:.   |:.:| |.|..||....:|.
  Fly   264 LDFDQSFFVAGWGGTEKETVATKLQQALITRKSLNECRQYY---NKGEV-SDNHICATGTGIKH- 323

Human   663 ACQGDSGG--VFAVRDPNTDRWVATGIVSWGIG--CSRGY-GFYTKVLNYVDWIKKEME 716
            .|||||||  .|..|..||.|.|..|:||:| |  |.:.. |.:..|::.:.||.:.::
  Fly   324 TCQGDSGGPVFFKHRFKNTYRVVQYGVVSFG-GRLCGQNQPGVFASVIDMLPWITQNLQ 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569	1/2 (50%)
		Sushi	390..461	CDD:306569	15/94 (16%)
		Tryp_SPc	477..711	CDD:214473	75/256 (29%)
CG5909	NP_651544.1	CLIP	25..82	CDD:197829	11/58 (19%)
		Tryp_SPc	129..376	CDD:214473	75/256 (29%)
		Tryp_SPc	132..379	CDD:238113	77/256 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910