DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG11836

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_001356925.1	Gene:	CG11836 / 43007	FlyBaseID:	FBgn0039272	Length:	333	Species:	Drosophila melanogaster

Alignment Length:	253	Identity:	81/253 - (32%)
Similarity:	126/253 - (49%)	Gaps:	34/253 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   477 RIIGGQKAKMGNFPWQVFTNIHGR--GGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTN 539
            ||:||:...:..:||.......|:  .||:||...::|:|||.:     :....:.:.|..|..:
  Fly    96 RIVGGKPTGVNQYPWMARIVYDGKFHCGGSLLTKDYVLSAAHCV-----KKLRKSKIRVIFGDHD 155

Human   540 VE------ELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTF 598
            .|      .:.:.....|:..|..||     :||  .|||||.|...::....:.|||||..:
  Fly   156 QEITSESQAIQRAVTAVIKHKSFDPD-----TYN--NDIALLRLRKPISFSKIIKPICLPRYN-- 211

Human   599 YD-LGLMGYVSGFGVMEE--KIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLK 660
            || .|.:|.|.|:|...|  ::...:..|::|:.:...|.|......|:   :.:|.|||.||:
  Fly   212 YDPAGRIGTVVGWGRTSEGGELPSIVNQVKVPIMSITECRNQRYKSTRI---TSSMLCAGRPSM- 272

Human   661 QDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSR-GY-GFYTKVLNYVDWIKKEME 716
             |:|||||||...:  .|..::...||||||:||.| || |.|::|..::.|||..:|
  Fly   273 -DSCQGDSGGPLLL--SNGVKYFIVGIVSWGVGCGREGYPGVYSRVSKFIPWIKSNLE 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569
		Tryp_SPc	477..711	CDD:214473	77/246 (31%)
CG11836	NP_001356925.1	Tryp_SPc	97..325	CDD:238113	79/248 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910