DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG42613

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_001247185.1	Gene:	CG42613 / 42269	FlyBaseID:	FBgn0261262	Length:	1188	Species:	Drosophila melanogaster

Alignment Length:	766	Identity:	162/766 - (21%)
Similarity:	268/766 - (34%)	Gaps:	249/766 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    28 RAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDL--EPSEG------ 84
            |.||    ||.  |..::||......::.:.........|.||::||:.|:|  .|.:|
  Fly   278 RIGG----PQN--GSFSAPLLHNHRNHSRQCLYTFLAGPGQRVEVVFKSFNLRGSPPDGSAVGEL 336

Human    85 --CFYDYVKISADKKSL-----------GRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSN 136
              |.::|:.|.::.:|.           ||:||.:      ||.::  :|....:.::|   |||
  Fly   337 PSCVHEYMDIYSEVQSSEPAELINSPFGGRYCGTI------PPRRR--ISMYRAVAISF---FSN 390

Human   137 EENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRH 201
             :|.|...::|...:..|.:                         |..|...:..|
  Fly   391 -KNVTTDLFEGTFRFINASE-------------------------YEIGIPIAGSP--------- 420

Human   202 SCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPY 266
             |....:..:....:|.:.|..||.:||.|:.|.|....|....:.|:|.: ||: .....|||:
  Fly   421 -CSYTITPSMSVNKTGALISPTYPGAYPKDMSCTYQFLGESNQRVRLEFRD-FDL-FFGGPHCPF 482

Human   267 DQLQIYANGKN----IGEFCGKQRPPDLDTSSNAVDLLFFT---DESGDSRGWK--LRYTTEIIK 322
            |.:::|....|    ||.:||:||...|.:|.:::.:.|:|   ..:..:||:|  ..::...:|
  Fly   483 DYVKVYDGPDNSSALIGTYCGQQRNLVLYSSESSLFVHFYTLSRTANTQNRGFKGIYEFSESFVK 547

Human   323 ----------------CPQPKTLDE-----FTIIQNLQPQYQFR-------DYFIATCKQGYQLI 359
                            |.| |.|.:     |.    |.|.|.:.       .|||...:....|
  Fly   548 LDFIRENDGIHIRGSECDQ-KILSKKESTGFV----LSPNYPYPYIPKTVCRYFIYGMQDAQHL- 606

Human   360 EGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPY 424
              .:|...|.|.                       |:|..:           :|.:.:..|.:.|
  Fly   607 --ERVRLEFNAF-----------------------NIPKVE-----------HKDKSESNCTDGY 635

Human   425 YKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIG-GQKAKMGN 488
            .|:..:        |..|..|...:..|           :||      .:.||:|. |.:..|
  Fly   636 LKIYLK--------GQETADAYDKFDYE-----------LCG------NETQRVISEGPRLAM-- 673

Human   489 FPWQVFTN--IHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLG--NH 549
                ||::  :.|||          ....:| :..|::....|:.|.....|.|....|.|  |.
  Fly   674 ----VFSSGELQGRG----------FKGKYT-FETEYKIPGTAAPDGTCSFTYVSSSKKRGELNS 723

Human   550 PIRRVSVHP-DYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGF-GV 612
            |     .:| :|..|.:.::   :.|.|.:..||:..:...| ..||:.....|..|..:.| ..
  Fly   724 P-----RYPSNYPSDTNCSY---LFLAEADEQVTIVFDHFKI-KADNNANATAGAYGSGACFEDW 779

Human   613 MEEKIAHDLRFVRL-----------PVANPQACENWLRGKNRMDVFSQNMFCAG------HPSLK 660
            :|..:.:.....||           ||.:|:.... ||.....|   |....:|      ..|.|
  Fly   780 LEMYVVYRDNNDRLLGRYCGQTAPGPVESPRGAVG-LRITLHTD---QESVASGFKARYFFESAK 840

Human   661 QDACQGDSGGVFAVRD------PN-------TDRWVATGIVSWGIGCSRGY 698
            .||  ||.||.|:.:|      ||       ..|.:|:...:|.:....||
  Fly   841 SDA--GDCGGNFSNQDSGLITSPNWPAGYKAPGRGMASNACNWVMKARPGY 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483	30/131 (23%)
		FXa_inhibition	175..203	CDD:317114	3/27 (11%)
		CUB	207..316	CDD:278839	33/117 (28%)
		Sushi	323..385	CDD:306569	15/73 (21%)
		Sushi	390..461	CDD:306569	10/70 (14%)
		Tryp_SPc	477..711	CDD:214473	60/259 (23%)
CG42613	NP_001247185.1	CUB	277..404	CDD:238001	35/143 (24%)
		CUB	421..541	CDD:238001	34/121 (28%)
		CUB	564..691	CDD:238001	38/210 (18%)
		CUB	707..836	CDD:238001	30/141 (21%)
		CUB	846..969	CDD:238001	11/44 (25%)
		LDLa	987..1022	CDD:238060
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910