DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG31266

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_001138068.1	Gene:	CG31266 / 42071	FlyBaseID:	FBgn0051266	Length:	282	Species:	Drosophila melanogaster

Alignment Length:	283	Identity:	78/283 - (27%)
Similarity:	123/283 - (43%)	Gaps:	55/283 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   454 KGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPW----QVFTNIHGRGGGALLGDRWILTA 514
            :||.:|....:..........:.|:|||..|..||:||    |...:.| ..|..:|.:.|:|||
  Fly    28 RGEPLPGLANIERHRSTEAVPQGRVIGGTTAAEGNWPWIASIQNAYSYH-LCGAIILDETWVLTA 91

Human   515 AHT---LYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLE 576
            |..   |.|        .:|.|..|..:..:|. ...:.:.::.||.::.:...:|   |||||:
  Fly    92 ASCVAGLRP--------LNLLVVTGTVDWWDLY-APYYTVSQIHVHCNFDKPLYHN---DIALLQ 144

Human   577 LENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVR------LPVANPQACE 635
            |.:.:........|.|.|.|...:...:.: :|:|..|....:. |:::      |||   .||.
  Fly   145 LSSKIEFNDVTKNITLADIDELEEGDKLTF-AGWGSSEAMGTYG-RYLQEASGTYLPV---DACR 204

Human   636 NWLRGKNRMDVFSQNMFCAGHPSLKQD----ACQGDSGGVFAVRDPNTD---RWVATGIVSWGIG 693
            ..|:.::.:|:        ||..::.|    ||.||:||      |..|   |.|  ||.:||:.
  Fly   205 EKLQNQDDVDL--------GHVCVQMDAGQGACHGDTGG------PLIDEQQRLV--GIGNWGVP 253

Human   694 CSRGY-GFYTKVLNYVDWIKKEM 715
            |.||| ..|.:...|.|||:..|
  Fly   254 CGRGYPDVYARTAFYHDWIRTTM 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569	3/6 (50%)
		Tryp_SPc	477..711	CDD:214473	72/254 (28%)
CG31266	NP_001138068.1	Tryp_SPc	51..272	CDD:214473	72/254 (28%)
CG31266	NP_001138068.1	Tryp_SPc	52..275	CDD:238113	73/256 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840