DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG31326

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_650344.2	Gene:	CG31326 / 41728	FlyBaseID:	FBgn0051326	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	313	Identity:	78/313 - (24%)
Similarity:	117/313 - (37%)	Gaps:	106/313 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   468 PVNPVEQ-----------RQR------IIGGQKAKMGNFPW--QVFTNIHGRG-----GGALLGD 508
            ||:.|.|           |:|      |..|:..:.|..||  .:|......|     ||.|:..
  Fly   247 PVDLVPQQNPSSNGIPCGRERASTTPLIFQGKSLQRGQLPWLVAIFERRESNGPAFICGGTLIST 311

Human   509 RWILTAAHTLYPKEHEAQSNASLDVFLG------HTNVEELMKLGNHPIRRVS---VHPDYRQDE 564
            ..:|:|||.......:..: :.|.|.||      |::.|         .|.||   :|      |
  Fly   312 STVLSAAHCFRAPGRDLPA-SRLAVSLGRNTLAIHSDGE---------FRGVSQLIIH------E 360

Human   565 SYNF----EGDIALLELENSVTLGPNLLPICLPDNDTFYDL--GLMGYVSGFGVME--------E 615
            ::.|    |.|:||:.|:..|.....::||||.......||  ||..||:|:|..|        .
  Fly   361 NFQFKQFTEADLALVRLDEPVRYTDYIVPICLWSTSNRMDLPQGLKSYVAGWGPDETGTGNTEVS 425

Human   616 KIAHDLRFV-------RLP--VANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDA--CQGDSG 669
            |:. ||..|       .||  :..|.:                  .||    .|..|  |..|.|
  Fly   426 KVT-DLNIVSEANCALELPHVLVQPSS------------------LCA----KKTGAGPCASDGG 467

Human   670 GVFAVRDPNTDRWVATGIVSWGI------GCSRGY-GFYTKVLNYVDWIKKEM 715
            |...:|:  .|.||..|::|.|:      .|.... ..:|.|..:::|::::|
  Fly   468 GPLMLRE--QDVWVLRGVISGGVINEKENTCELSKPSVFTDVAKHIEWVRQKM 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569
		Tryp_SPc	477..711	CDD:214473	71/287 (25%)
CG31326	NP_650344.2	GD_N	26..126	CDD:292649
		Tryp_SPc	277..517	CDD:238113	70/280 (25%)
		Tryp_SPc	277..514	CDD:214473	69/277 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910