Protein Alignment C1R and CG31326

DIOPT Version :10

• Sequence 1: NP_001341275.1
• Gene: C1R / 715
• HGNCID: 1246
• Length: 719
• Species: Homo sapiens
• Sequence 2: NP_650344.2
• Gene: CG31326 / 41728
• FlyBaseID: FBgn0051326
• Length: 520
• Species: Drosophila melanogaster
• Alignment Length: 313
• Identity: 78/313 - (24%)
• Similarity: 117/313 - (37%)
• Gaps: 106/313 - (33%)

Human   468 PVNPVEQ-----------RQR------IIGGQKAKMGNFPW--QVFTNIHGRG-----GGALLGD 508
            ||:.|.|           |:|      |..|:..:.|..||  .:|......|     ||.|:..
  Fly   247 PVDLVPQQNPSSNGIPCGRERASTTPLIFQGKSLQRGQLPWLVAIFERRESNGPAFICGGTLIST 311

Human   509 RWILTAAHTLYPKEHEAQSNASLDVFLG------HTNVEELMKLGNHPIRRVS---VHPDYRQDE 564
            ..:|:|||.......:..: :.|.|.||      |::.|         .|.||   :|      |
  Fly   312 STVLSAAHCFRAPGRDLPA-SRLAVSLGRNTLAIHSDGE---------FRGVSQLIIH------E 360

Human   565 SYNF----EGDIALLELENSVTLGPNLLPICLPDNDTFYDL--GLMGYVSGFGVME--------E 615
            ::.|    |.|:||:.|:..|.....::||||.......||  ||..||:|:|..|        .
  Fly   361 NFQFKQFTEADLALVRLDEPVRYTDYIVPICLWSTSNRMDLPQGLKSYVAGWGPDETGTGNTEVS 425

Human   616 KIAHDLRFV-------RLP--VANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDA--CQGDSG 669
            |:. ||..|       .||  :..|.:                  .||    .|..|  |..|.|
  Fly   426 KVT-DLNIVSEANCALELPHVLVQPSS------------------LCA----KKTGAGPCASDGG 467

Human   670 GVFAVRDPNTDRWVATGIVSWGI------GCSRGY-GFYTKVLNYVDWIKKEM 715
            |...:|:  .|.||..|::|.|:      .|.... ..:|.|..:::|::::|
  Fly   468 GPLMLRE--QDVWVLRGVISGGVINEKENTCELSKPSVFTDVAKHIEWVRQKM 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:464251
		CUB	207..316	CDD:395345
		Sushi	323..385	CDD:459664
		CCP	390..461	CDD:153056
		Tryp_SPc	477..711	CDD:214473	71/287 (25%)
CG31326	NP_650344.2	GD_N	26..131	CDD:464985
		PHA03378	<101..278	CDD:223065	7/30 (23%)
		Tryp_SPc	277..517	CDD:238113	70/280 (25%)