DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG11668

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_650254.1	Gene:	CG11668 / 41606	FlyBaseID:	FBgn0038113	Length:	398	Species:	Drosophila melanogaster

Alignment Length:	283	Identity:	68/283 - (24%)
Similarity:	124/283 - (43%)	Gaps:	56/283 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   469 VNPVEQRQR-----IIGGQKAKMGNFP------WQVFTN--IHGRG----------GGALLGDRW 510
            |.|:.|:..     ::||:..:....|      |...||  ||..|          |.|::..|:
  Fly   134 VEPIIQKHNQSQNLLVGGRLTQENEHPYMCALGWPSRTNRWIHEHGSSKRRYTFNCGCAMIAPRF 198

Human   511 ILTAAHTLYPKEHEAQSNA---SLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDI 572
            .:||||.. ....|:.|.|   .:::..|...:.|        |:|:|.||.:   ::.....|:
  Fly   199 AITAAHCA-SVGGESPSVALIGGVELNSGRGQLIE--------IKRISQHPHF---DAETLTNDL 251

Human   573 ALLELENSVTLGPNLLPI-CLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPV--ANPQAC 634
            |:::|...     :.:|: ||.:.::..:..|...  |:|..:....|....:::.:  .|.|.|
  Fly   252 AVVKLARR-----SHMPVACLWNQESLPERPLTAL--GYGQTKFAGPHSSNLLQIMLYHLNFQQC 309

Human   635 ENWLRGKNRM-DVFSQNMFCAGHPSLKQDACQGDSGGVFAVRD-----PNTDRWVATGIVSWGIG 693
            :.:|...::: :.......|||..|...|.|||||||...:..     .:|..:| .||.|:|..
  Fly   310 QRYLHNYDKLANGLGSGQMCAGDYSGNMDTCQGDSGGPLLLHQHMRHHRHTIPYV-VGITSFGGA 373

Human   694 CSRGY-GFYTKVLNYVDWIKKEM 715
            |:.|. |.|.::.:|:.||::::
  Fly   374 CASGQPGVYVRIAHYIQWIEQQV 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569
		Tryp_SPc	477..711	CDD:214473	63/269 (23%)
CG11668	NP_650254.1	Tryp_SPc	149..395	CDD:238113	65/265 (25%)
CG11668	NP_650254.1	Tryp_SPc	149..392	CDD:214473	63/262 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910