DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C1R and Sp7

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_649734.2	Gene:	Sp7 / 40918	FlyBaseID:	FBgn0037515	Length:	391	Species:	Drosophila melanogaster

Alignment Length:	424	Identity:	113/424 - (26%)
Similarity:	162/424 - (38%)	Gaps:	101/424 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   332 FTIIQNLQPQYQFRDYFIATCKQGYQL-IEGNQVLHSF---TAVCQDDGTWHRAMPRCKIKDCGQ 392
            ||::||:..|...|:   ...|||..| |...|.|.|.   :.|..:|.|:.|.      ..|
  Fly    19 FTVLQNVAAQGSCRN---PNQKQGQCLSIYDCQSLLSVIQQSYVSPEDRTFLRN------SQC-- 72

Human   393 PRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEK 457
                         ..||    .|..|.|    .......||:|:.......|........|.|:.
  Fly    73 -------------LDGV----GRQPYVC----CTSDRSFGSQEATSAAPPPTTTSSSSRGQDGQA 116

Human   458 -----IPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTN-IHGRG------GGALLGDRW 510
                 :| ..|.||    |.....::..|....:..|.|..... :..||      ||:|:.:|:
  Fly   117 GLGNLLP-SPPKCG----PHSFSNKVYNGNDTAIDEFNWMALLEYVDNRGRRELSCGGSLINNRY 176

Human   511 ILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLG---------------NHP-----IRRVS 555
            :|||||.:.         .:::..:||...   ::||               |.|     |.:.:
  Fly   177 VLTAAHCVI---------GAVETEVGHLTT---VRLGEYDTSKDVDCIDDICNQPILQLGIEQAT 229

Human   556 VHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDT--FYDLGLMGYVSGFG----VME 614
            |||.| ...:.|...|||||.|:..|.|...:.|:|||...|  ..:.|.:..|||:|    ..:
  Fly   230 VHPQY-DPANKNRIHDIALLRLDRPVVLNEYIQPVCLPLVSTRMAINTGELLVVSGWGRTTTARK 293

Human   615 EKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNT 679
            ..|...|   .|||.:...|......:|...:.||  .|.| ....:|:|.|||||.. :|....
  Fly   294 STIKQRL---DLPVNDHDYCARKFATRNIHLISSQ--LCVG-GEFYRDSCDGDSGGPL-MRRGFD 351

Human   680 DRWVATGIVSWGIGCS-RGY-GFYTKVLNYVDWI 711
            ..|...|:||:|..|. .|: |.||:|.:|:|||
  Fly   352 QAWYQEGVVSFGNRCGLEGWPGVYTRVADYMDWI 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569	18/56 (32%)
		Sushi	390..461	CDD:306569	13/75 (17%)
		Tryp_SPc	477..711	CDD:214473	76/268 (28%)
Sp7	NP_649734.2	CLIP	31..84	CDD:288855	19/84 (23%)
		Tryp_SPc	136..385	CDD:214473	76/268 (28%)
		Tryp_SPc	137..388	CDD:238113	78/269 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910