DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG6865

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_001246825.1	Gene:	CG6865 / 40050	FlyBaseID:	FBgn0036817	Length:	285	Species:	Drosophila melanogaster

Alignment Length:	266	Identity:	80/266 - (30%)
Similarity:	128/266 - (48%)	Gaps:	34/266 - (12%)

- Green bases have known domain annotations that are detailed below.

Human   470 NPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRG----GGALLGDRWILTAAHTLYPKEHEAQSNAS 530
            ||     :|:||.:|:....|:.|  ::..||    ||.::.:||||||.|.:.....:....|.
  Fly    32 NP-----KIVGGSEAERNEMPYMV--SLMRRGGHFCGGTIISERWILTAGHCICNGLQQFMKPAQ 89

Human   531 LDVFLG-HTNVEELMKLGNHP------IRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLL 588
            :...:| |:..|.|..:||.|      .:.:..||.|   :..:.:.|||||||...:....::.
  Fly    90 IQGVVGLHSIREYLNGIGNGPDALRVDFKNIVPHPQY---DCNDVKHDIALLELVQPIRFSSHIQ 151

Human   589 PICLPDNDTFYDLGL-MGYVSGFGVMEEKIAHD-----LRFVRLPVANPQACENWLRGKNRMDVF 647
            |.|:...:....|.. .|.|||:|...|..|.:     ||...:.:.|.:|||...|...:.:..
  Fly   152 PSCVGSEEGHRSLEQEYGTVSGWGWTHENQAENDRSDVLRKATVKIWNNEACERSYRSLGKSNTI 216

Human   648 SQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSR-GY-GFYTKVLNYVDW 710
            .:...|||:.:.:.|:|..||||....::.:     ..|:||.||||:| |. |.||:|..||.|
  Fly   217 GETQLCAGYENGQIDSCWADSGGPLMSKEHH-----LVGVVSTGIGCARPGLPGIYTRVSKYVSW 276

Human   711 IKKEME 716
            ::|.::
  Fly   277 MQKVID 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569
		Tryp_SPc	477..711	CDD:214473	76/252 (30%)
CG6865	NP_001246825.1	Tryp_SPc	34..276	CDD:214473	76/251 (30%)
CG6865	NP_001246825.1	Tryp_SPc	35..280	CDD:238113	77/254 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910