DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C1R and ndl

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_523947.2	Gene:	ndl / 38738	FlyBaseID:	FBgn0002926	Length:	2616	Species:	Drosophila melanogaster

Alignment Length:	830	Identity:	181/830 - (21%)
Similarity:	268/830 - (32%)	Gaps:	300/830 - (36%)

- Green bases have known domain annotations that are detailed below.

Human    28 RAGGSIPIPQKL------------FGEVTSPLFPKPYPNNFETTTVITVPT-------------- 66
            ||.|..|:..:.            ||..:.|:.....|.||........||
  Fly   705 RAPGGFPVSGETMKASAQFMFNPNFGMPSIPVCFYMTPANFRMPMWSNTPTFMGMQGAHFGGSSN 769

Human    67 -GYRVKLVFQQFDLEPS--------------EGCFYDYVKISADKKSLGR---FCGQLGSPLGNP 113
             |..:..|.|||.  ||              :|........|..|.:.|:   :|..:.:..|..
  Fly   770 PGAGIFFVPQQFG--PSGNFFGGSGGSGAGGQGANIFSKNASPQKPTNGQQQVYCSYMQNQSGQG 832

Human   114 PGKKEFMSQ---------GNKMLLTFHTDFSNEEN--GTIMFYKGFLAYYQAVDLDECASRSKSG 167
            .|:.:..||         .|......|.:.:|..|  |.|::     |.|..:.......||:..
  Fly   833 AGQSQTSSQQQQGGQSAFSNANFKMRHANQTNTANQQGQIIY-----ASYAGLPQQPIQERSRCP 892

Human   168 EEDP-----QPQC---QHLCHNYV------GGYFCSCR---------PGYE---LQEDRHSCQAE 206
            |.|.     |.:|   ...|.|.|      ....|:|.         .|||   :.||...|..
  Fly   893 EPDQFSCFGQQECIPAARWCDNVVDCSDGSDESACTCADRVDEERLCDGYEDCPMGEDELGCFG- 956

Human   207 CSSELYTEASGYISSLEYPRSYPPDLRCNYSI---RVERGLTLHLKFLEPFDIDDHQQVHCPYDQ 268
            |.|..|       |..|.|:.:....|...|:   |:||                     |  |.
  Fly   957 CESLAY-------SCYENPQDFAKRNRSTISMCYSRLER---------------------C--DG 991

Human   269 LQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGD-SRGWKLRYTTEIIKCPQPKTLDEF 332
            .....||:: .|.|.                :..||.:.. |.|
  Fly   992 FMNCLNGRD-EEQCS----------------MLVTDVADHMSHG--------------------- 1018

Human   333 TIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTA----VCQDDGTWHRAMPRCKIKDCG-- 391
                             |:..:||       :.|::..    ||.:...|  |...|::.:..
  Fly  1019 -----------------ASASEGY-------LYHNYRGDWHPVCNNGEKW--AALACQMDENSRM 1057

Human   392 ----------QPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQ 446
                      |...||......:...||:..:|     ||           .|.|...:....|
  Fly  1058 DHSASLNVSFQTLTLPGPFIEPSLHAGVHFAQA-----CH-----------GRNSHDSLVDHVA- 1105

Human   447 GIWKNEQKGEKIPRCLPV-CGKPV------------NPVEQRQRIIGGQKAKMGNF----PWQVF 494
                       ..:|.|: ||.|.            ..|...:.|:|..:...|::    .|...
  Fly  1106 -----------YVKCPPMQCGLPSKSSMLEHSKRVRRAVSDSKEIVGDGRIVGGSYTSALQWPFV 1159

Human   495 TNIHGRG----GGALLGDRWILTAAHTL--YPKE-HEAQSNASLDVFLGHTNVEELMKLGNHPIR 552
            ..|:..|    ||.:..||||::|||.:  |.|. :|.::.     .|..::.....::  .|:.
  Fly  1160 VAIYRNGKFHCGGTIYSDRWIISAAHCVINYGKYFYEVRAG-----LLRRSSYSPATQI--QPVS 1217

Human   553 RVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPD--NDTFYDLGLMGYVS------- 608
            .|.||..|   |..:...|::||.|.|.:.....:.||||||  ..|..|..:.|.|.
  Fly  1218 HVVVHQAY---ERRSMRNDLSLLRLLNPLQFNRWVKPICLPDKGRTTVGDDWIWGPVEHTLCTVV 1279

Human   609 GFGVMEEK--IAHDLRFVRLPV----ANP--QACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQ 665
            |:|.:.||  .:..:|.|.:|:    .:|  ||.|:               .|||.|...:||||
  Fly  1280 GWGAIREKGPSSDPMRQVIVPIRKKCTDPEDQASED---------------ICAGDPDGGRDACQ 1329

Human   666 GDSGG-VFAVRDPNTDRWVATGIVSWGIGCSR--GYGFYTKVLNYVDWIK 712
            ||||| :|.....|.|.:...|:||.|.||:|  .:|.||:|..|:||::
  Fly  1330 GDSGGPLFCRSVSNPDEFYLAGVVSHGNGCARPQEFGVYTRVTLYLDWLE 1379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483	30/153 (20%)
		FXa_inhibition	175..203	CDD:317114	11/48 (23%)
		CUB	207..316	CDD:278839	21/112 (19%)
		Sushi	323..385	CDD:306569	8/65 (12%)
		Sushi	390..461	CDD:306569	11/82 (13%)
		Tryp_SPc	477..711	CDD:214473	80/264 (30%)
ndl	NP_523947.2	LDLa	891..927	CDD:238060	7/35 (20%)
		Tryp_SPc	1144..1377	CDD:214473	77/257 (30%)
		Tryp_SPc	1145..1379	CDD:238113	79/258 (31%)
		LDLa	1399..1430	CDD:238060
		Metaviral_G	1448..1600	CDD:118131
		LDLa	1710..1743	CDD:238060
		LDLa	1776..1811	CDD:238060
		DUF1986	2041..2158	CDD:286432
		LDLa	2309..2339	CDD:197566
		LDLa	2350..2383	CDD:197566
		LDLa	2421..2457	CDD:238060
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910