DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C1R and CG10477

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_001303385.1	Gene:	CG10477 / 38679	FlyBaseID:	FBgn0035661	Length:	272	Species:	Drosophila melanogaster

Alignment Length:	270	Identity:	76/270 - (28%)
Similarity:	121/270 - (44%)	Gaps:	49/270 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   468 PVNPVEQRQ------RIIGGQKAKMGNFPWQV---FTNIHGRG--GGALLGDRWILTAAHTLYPK 521
            ||:|.:...      ||..|.||....||:||   |.:..|..  ||:::.:.|:|||||.
  Fly    24 PVHPRDSSAVPSIDGRITNGNKAAANQFPYQVGLSFKSSAGSWWCGGSIIANTWVLTAAHC---- 84

Human   522 EHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYN---FEGDIALLELENSVTL 583
               .:..:|:.::.|.| |....||.    ::|| ...:.|...||   ...||:|::.. |||.
  Fly    85 ---TKGASSVTIYYGST-VRTSAKLK----KKVS-SSKFVQHAGYNAATLRNDISLIKTP-SVTF 139

Human   584 GPNLLPICLPDNDTFYD--LGLMGYVSGFGVMEEK---IAHDLRFVRLPVANPQACENWLRGKNR 643
            ..::..|.||...:.|.  .|.....||:|...:.   :|.:|::.:..|.....|:.....
  Fly   140 TVSINKIALPAIASSYSTYAGQTAVASGWGRTSDSSIAVATNLQYAQFQVITNAVCQKTFGS--- 201

Human   644 MDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSW--GIGCSRG--YGFYTKV 704
             .|.:..:.|....: |:..|||||||..|:    .:|.:  |:.|:  ..||.:.  .|| |:|
  Fly   202 -SVVTSGVICVESIN-KKSTCQGDSGGPLAL----NNRLI--GVTSFVSSKGCEKNAPAGF-TRV 257

Human   705 LNYVDWIKKE 714
            .:|:||||.:
  Fly   258 TSYLDWIKNQ 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569
		Tryp_SPc	477..711	CDD:214473	70/250 (28%)
CG10477	NP_001303385.1	Tryp_SPc	39..264	CDD:214473	70/250 (28%)
CG10477	NP_001303385.1	Tryp_SPc	40..267	CDD:238113	72/252 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910