DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and mas

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_523919.1	Gene:	mas / 38499	FlyBaseID:	FBgn0011653	Length:	1047	Species:	Drosophila melanogaster

Alignment Length:	431	Identity:	99/431 - (22%)
Similarity:	168/431 - (38%)	Gaps:	89/431 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   317 TTEIIKCPQPKTLDEF------TIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDD 375
            ||.....|:|....::      |:.........|..|  |..|.|.|     :.....|:.....
  Fly   665 TTTTTTTPRPHVYSKYVCGVKGTLRTGRSQALSFVSY--ARAKYGVQ-----RTARQMTSAAGYS 722

Human   376 GTWHRAMPRCKIKDCGQPRNLPN---GDFRYTTTMGVNTYKARIQYYCHE-----------PYYK 426
            ..::::..|..:.....|..:.|   ||...::::..|..::   |:.|:           .||:
  Fly   723 PNFNKSNERLVLGSAIVPIQIHNDKLGDLVESSSLQSNQLRS---YHNHQAQADQPDLVYPEYYQ 784

Human   427 MQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPW 491
            .::..|.:.:..|                                 .:|.|::||:..:.|.:.|
  Fly   785 QRSLYGLQSNFSG---------------------------------RRRARVVGGEDGENGEWCW 816

Human   492 QVFTNIHGRG----GGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIR 552
            || ..|:...    |.||:|.:|:|||||.:   .:..:|..::.|.:|..::..  |.|:...:
  Fly   817 QV-ALINSLNQYLCGAALIGTQWVLTAAHCV---TNIVRSGDAIYVRVGDYDLTR--KYGSPGAQ 875

Human   553 RVSVHPDY--RQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEE 615
            .:.|...|  ....|...:.|||||:|.....|...:..:|||.....:..|....|:|:|.|.|
  Fly   876 TLRVATTYIHHNHNSQTLDNDIALLKLHGQAELRDGVCLVCLPARGVSHAAGKRCTVTGYGYMGE 940

Human   616 --KIAHDLRFVRLPVANPQACENWLRGKN----RMDVFSQNMFCAGHPSLKQDACQGDSGGVFAV 674
              .|...:|...:|:.:...|   :|..|    ::.:...:.||||... ..||||||.||....
  Fly   941 AGPIPLRVREAEIPIVSDTEC---IRKVNAVTEKIFILPASSFCAGGEE-GHDACQGDGGGPLVC 1001

Human   675 RDPNTDRWVATGIVSWGIGCSRG--YGFYTKVLNYVDWIKK 713
            :|...  :...|:||||.||.|.  .|.|.|..:::.||.:
  Fly  1002 QDDGF--YELAGLVSWGFGCGRQDVPGVYVKTSSFIGWINQ 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569	10/67 (15%)
		Sushi	390..461	CDD:306569	11/84 (13%)
		Tryp_SPc	477..711	CDD:214473	72/247 (29%)
mas	NP_523919.1	Tryp_SPc	803..1041	CDD:238113	73/250 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910