DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG13430

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_001027441.1	Gene:	CG13430 / 3772580	FlyBaseID:	FBgn0034518	Length:	267	Species:	Drosophila melanogaster

Alignment Length:	259	Identity:	76/259 - (29%)
Similarity:	123/259 - (47%)	Gaps:	32/259 - (12%)

- Green bases have known domain annotations that are detailed below.

Human   472 VEQRQRIIGGQKAKMGNFPWQVFTNIHGRG--GGALLGDRWILTAAHTLY----PKEHEAQSNAS 530
            |||..||:||.:..:..||.||...:..|.  ||.::....||||||.:.    |:.:..::.:|
  Fly    26 VEQDGRIVGGWETHITFFPHQVSLQLGTRHACGGTIISPNIILTAAHCVLEYSKPQYYVIRAGSS 90

Human   531 LDVFLGHTNVEELMKLGNH-PIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPD 594
                       :..|.|:: .::::..||::......|  .|||:::|:..:....::.||.|..
  Fly    91 -----------DWTKGGSYIRVKKIIPHPEFHDPTRMN--NDIAIVQLQQPLVYSQDIRPISLAT 142

Human   595 NDTFYDLGLMGYVSGFG---VMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGH 656
            :..........:|||:|   :.:.:....||:..:.:.:...|.....|...:   :..|||||.
  Fly   143 SKDIIMPTAQLFVSGWGSTSISQMQPEKRLRYTVVHLRDQNQCARNYFGAGTV---TNTMFCAGT 204

Human   657 PSLKQDACQGDSGGVFAVRDPNTD-RWVATGIVSWGIGCSRGY--GFYTKVLNYVDWIKKEMEE 717
            .:..:|:|||||||....   :.| |....||||||.||:...  |.||||..|.|||.:.:||
  Fly   205 QAGGRDSCQGDSGGPLVT---SIDGRLKLYGIVSWGFGCANAMFPGIYTKVSAYDDWIAQTIEE 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569
		Tryp_SPc	477..711	CDD:214473	69/246 (28%)
CG13430	NP_001027441.1	Tryp_SPc	31..259	CDD:214473	69/246 (28%)
CG13430	NP_001027441.1	Tryp_SPc	32..262	CDD:238113	70/248 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910