DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG13744

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_610439.1	Gene:	CG13744 / 35906	FlyBaseID:	FBgn0033363	Length:	389	Species:	Drosophila melanogaster

Alignment Length:	272	Identity:	84/272 - (30%)
Similarity:	123/272 - (45%)	Gaps:	36/272 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   463 PVCGKPVNPVEQRQ-RIIGGQKAKMGNFPWQVFTNI-HGRGGGALLGDRWILTAAHTLYPKEHEA 525
            |.||.|.......| |||||:.|:...:|||....| ..:.||.|:....:.||||.:     :.
  Fly   126 PECGVPRTAQNTLQKRIIGGRPAQFAEYPWQAHIRIAEYQCGGVLISANMVATAAHCI-----QQ 185

Human   526 QSNASLDVFLGHTNVEEL------MKLGNHPIRRVSVHPDYR----QDESYNFEGDIALLELENS 580
            ...|.:.|:||..:.::|      :.:..|.:.:..:||.:.    |.:.|    |||||:|...
  Fly   186 AHLADITVYLGELDTQDLGHIHEPLPVEKHGVLQKIIHPRFNFRMTQPDRY----DIALLKLAQP 246

Human   581 VTLGPNLLPICLPDNDTFYD---LGLMGYVSGFGVMEEKIAHD----LRFVRLPVANPQACENWL 638
            .:...::||||||.    |.   :|..|.::|:|..|..:.|.    |:...:|:.....|..|.
  Fly   247 TSFTEHILPICLPQ----YPIRLIGRKGLIAGWGKTEAHMGHAGTNMLQVASVPIITTLDCIRWH 307

Human   639 RGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGY--GFY 701
            ..|.........||||||.....|||.|||||...:::  ..|:|..||.|.|.||...:  |.|
  Fly   308 ESKQINVEIKAEMFCAGHSDGHMDACLGDSGGPLVIKE--RGRFVLVGITSAGFGCGVDHQPGIY 370

Human   702 TKVLNYVDWIKK 713
            ..|...|.||::
  Fly   371 HNVQKTVRWIQE 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569
		Tryp_SPc	477..711	CDD:214473	77/253 (30%)
CG13744	NP_610439.1	Tryp_SPc	141..380	CDD:214473	77/253 (30%)
CG13744	NP_610439.1	Tryp_SPc	142..383	CDD:238113	78/256 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6509
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860