DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG8586

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_001286204.1	Gene:	CG8586 / 35854	FlyBaseID:	FBgn0033320	Length:	444	Species:	Drosophila melanogaster

Alignment Length:	366	Identity:	99/366 - (27%)
Similarity:	153/366 - (41%)	Gaps:	72/366 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   388 KDCGQ-----PRNLPNGDFRYTTTMGVNTYKARIQ-YYCHEPYYK---MQTRAGSRESEQGVYTC 443
            :.|||     ||.|...:.  ....|::....||. ..|.:..|:   :..:....||...|
  Fly   103 ESCGQNMECVPRKLCRDNI--INDSGISLINPRISPIQCSKSLYRCCAVDQKVDDSESPYLV--- 162

Human   444 TAQGIWKNEQKGEKIPRCLPVCGKPVN---PVEQRQRIIGGQKAKMGNFPWQV--FTNIHGRG-- 501
             .|..:|.:..|...|:.|    .|.|   |..:...|       .|.|||.|  ||   ||.
  Fly   163 -KQANFKYKNCGYSNPKGL----IPDNDKFPYSEDVSI-------FGEFPWMVGIFT---GRQEF 212

Human   502 --GGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHP-------IRRVSVH 557
              ||.|:..|.::|.:|.|.        |.::|..:......:|..| |.|       |:.:.:|
  Fly   213 LCGGTLIHPRLVVTTSHNLV--------NETVDTLVARAGDWDLNSL-NEPYPHQGSRIKEIIMH 268

Human   558 PDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDND----TFYDLGLMGYVSGFGVME---E 615
            .::..:..||   |||||.|:..:.|.|::.|:|||..:    |...|.:..|.:|:|..|   :
  Fly   269 SEFDPNSLYN---DIALLLLDEPIRLAPHIQPLCLPPPESPELTNQLLSVTCYATGWGTKEAGSD 330

Human   616 KIAHDLRFVRLPVANPQACENWLRGKNRMDV---FSQNMFCAGHPSLKQDACQGDSGG-VFAVRD 676
            |:.|.|:.:.||:...:.|:..|| ..|::.   ...:..|||....| |.|:||.|. :|....
  Fly   331 KLEHVLKRINLPLVEREECQAKLR-NTRLEARFRLRPSFICAGGDPGK-DTCKGDGGSPLFCQMP 393

Human   677 PNTDRWVATGIVSWGIGCSRG--YGFYTKVLNYVDWIKKEM 715
            ...||:...||||||:.|:..  ...|..|.:...||.:::
  Fly   394 GEMDRYQLVGIVSWGVECAVEDIPAVYVNVPHLRGWIDEKI 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569	18/79 (23%)
		Tryp_SPc	477..711	CDD:214473	75/259 (29%)
CG8586	NP_001286204.1	Tryp_SPc	197..433	CDD:238113	76/252 (30%)
CG8586	NP_001286204.1	Tryp_SPc	197..430	CDD:214473	74/249 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910