DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C1R and Corin

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster

Alignment Length:	913	Identity:	204/913 - (22%)
Similarity:	305/913 - (33%)	Gaps:	328/913 - (35%)

- Green bases have known domain annotations that are detailed below.

Human     8 GREENA------QWWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPN-NFETTTVI--- 62
            ||:.||      |..|:.|........|||.....::      .|..|.|... ||...:.|
  Fly   558 GRKSNAPGSAQRQTPLMDLAPTRFLGGAGGGTGSGKQ------GPAMPPPRSKINFRQDSTISSD 616

Human    63 ----TVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKSLGRFCG------------------- 104
                |...||..||:  :..|.||         :||.     |.|.
  Fly   617 SFSQTSSPGYNPKLM--EAPLLPS---------LSAK-----RLCSAPAPIVCRQGVQHEPIEEL 665

Human   105 ---QLGSPL----GNPP----------GKKEFMSQGNKMLLTFHTDFSNEENGTIMF-------- 144
               |..|||    |.|.          |....||..::::....:......||.:.|
  Fly   666 EPPQTISPLHKAAGQPSSLQTIVRFQNGAPHTMSLQHQIINRRKSSNPYITNGRLKFRLFQILIN 730

Human   145 -------YKGFLAYYQA--------------VDLDECASRSKSGEEDPQPQ---------CQ--H 177
                   ..|..||:.|              :.:::..|..|    :|.|.         ||  .
  Fly   731 AFALLAIAGGLAAYFNAYPTIKFVNKTIINTIHVEDTTSFGK----NPAPGTCLPIIVRFCQGPQ 791

Human   178 LCHNYVGGYFCSCRPGY-------ELQEDRHSCQAECSSELYTEASGYISSLEYPR------SYP 229
            :.:||      :..|.|       |.|.|..|.:|......|...|.::.:|..|:      :.|
  Fly   792 IPYNY------TVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSGATVP 850

Human   230 P--------DLRCNYSIRVERGLT----LHLKFLEPF-------DIDDHQQVHCPYDQLQIYANG 275
            |        ..||.:...| .||:    |:.|..:.|       .:|:.::|      ::...:.
  Fly   851 PCKTLCTETMRRCGFFFDV-FGLSLPEYLNCKLFKDFPSSEDCVGLDEVREV------MRAATHP 908

Human   276 KNIGEFCGKQR-PPDLDTSSNAVDLLFFTDES------------GDSRGWKLRYTTE-IIKCPQP 326
            |..|..|.:.| .|........:|.:...||:            |||:....::..: ||.||..
  Fly   909 KCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTKHICDGIIDCPYG 973

Human   327 K------------------TLDEFTIIQNLQPQYQFRDYFIATCKQ--------------GYQLI 359
            :                  .|:.:.|.|        |.:..|..|.              ||..:
  Fly   974 QDERNCLRLSERNGDVGTGVLEVYRIGQ--------RQWMPACVKNWDRAVSPSAVCSILGYSAV 1030

Human   360 EGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPY 424
            ....||...|         ||.:                     ..|:.|:|           ..
  Fly  1031 NATSVLTQLT---------HRPL---------------------LATVNVST-----------DI 1054

Human   425 YKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCG------------KPVNPVEQRQR 477
            :||..:..|          |....:.|.:|.|..|.....|.            ||      .:|
  Fly  1055 WKMYAKRKS----------TLMQEFANCKKTEDYPMADLTCSNYECGRVKRGRHKP------SRR 1103

Human   478 IIGGQKAKMGNFPWQVFTNIHGRGG--------GALLGDRWILTAAHTLYPKEHEAQSNASL--- 531
            ||||.:|..||:|:....    .||        |.|:.|:|:|||:|.:        .|.|:
  Fly  1104 IIGGTQASPGNWPFLAAI----LGGPEKIFYCAGVLISDQWVLTASHCV--------GNYSVIDL 1156

Human   532 ---DVFLGHTNVEELMKLGNH-PIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICL 592
               .:.||.|........|.. .::.|..||.|....::  :.||||.:|...|....:|||:||
  Fly  1157 EDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAH--DNDIALFQLATRVAFHEHLLPVCL 1219

Human   593 PDNDTFYDL--GLMGYVSGFGVMEEK-----IAHDLRFVRLPVANPQACENWLRGKNRMDVFSQN 650
            |. .:..:|  |.:..|.|:|..|:|     ..:.:..|::|:.....|:.||   :.:.| |:.
  Fly  1220 PP-PSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWL---DNLTV-SEG 1279

Human   651 MFCAGHPSLKQDACQGDSGGVFAVRDP-NTDRWVATGIVSWGIGCS--RGYGFYTKVLNYVDWIK 712
            |.|||.....:|||||||||......| ..:||...|||||||.|:  |..|.|..|:.||.||:
  Fly  1280 MVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQ 1344

Human   713 KEM 715
            :::
  Fly  1345 EQI 1347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483	32/169 (19%)
		FXa_inhibition	175..203	CDD:317114	9/36 (25%)
		CUB	207..316	CDD:278839	27/146 (18%)
		Sushi	323..385	CDD:306569	15/93 (16%)
		Sushi	390..461	CDD:306569	11/70 (16%)
		Tryp_SPc	477..711	CDD:214473	85/258 (33%)
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	25/122 (20%)
		LDLa	911..942	CDD:238060	7/30 (23%)
		LDLa	945..979	CDD:238060	7/33 (21%)
		SR	980..>1034	CDD:214555	8/61 (13%)
		SRCR	992..1086	CDD:278931	24/152 (16%)
		Tryp_SPc	1103..1343	CDD:214473	85/258 (33%)
		Tryp_SPc	1104..1346	CDD:238113	86/260 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910