DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and l(2)k05911

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_723797.3	Gene:	l(2)k05911 / 34731	FlyBaseID:	FBgn0284244	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	482	Identity:	130/482 - (26%)
Similarity:	198/482 - (41%)	Gaps:	82/482 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   267 DQLQIYANGKNIGEFCGKQRPPD-------LDTSSNAVDLLFFTDES---GDSRGWKLRYTTEII 321
            |:..:...|:..|.:     |||       :|.:::..|...|.|.:   |:..|...:...|.:
  Fly   208 DREHVIPEGEVEGVY-----PPDVPRPEEPIDNANSVEDTPDFQDINTIEGNPPGADKKPEAEPV 267

Human   322 KCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCK 386
            ..|..:.:       :.||         |:....||...|     ||..     |.|..|:|...
  Fly   268 GEPVEQPI-------STQP---------ASTIHPYQWPFG-----SFAG-----GQWPPALPTHP 306

Human   387 IKDCGQPRNL----PNGDF-RYTTTMGVNTYKARIQYYCHEPYYKMQTRA---GSRESEQGVYTC 443
            ....|.|..|    ||..: .:.||.||.:.| |.......|.....||.   .|..|.....|.
  Fly   307 PTTGGWPPPLPTHPPNHHYPTHPTTGGVPSTK-RTTPRPTSPARPTTTRRPTYPSYPSPVTTTTT 370

Human   444 TAQGIWKNEQKGEKIPRCLPV-CG--KPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRG--GG 503
            |.:.:.....:|      ||: ||  .||.|  .::||:||..|....|||.......|:.  ||
  Fly   371 TRRPVSGTSSEG------LPLQCGNKNPVTP--DQERIVGGINASPHEFPWIAVLFKSGKQFCGG 427

Human   504 ALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNF 568
            :|:.:..||||||.:  ....:...|:|...||..|:....:: .|..||:.....::..|....
  Fly   428 SLITNSHILTAAHCV--ARMTSWDVAALTAHLGDYNIGTDFEV-QHVSRRIKRLVRHKGFEFSTL 489

Human   569 EGDIALLELENSVTLGPNLLPICLPDNDT----FYDLGLMGYVSGFGVMEEKIAHD--LRFVRLP 627
            ..|:|:|.|...|.....:.|||||.:.:    .|. |.:..|:|:|.:.|.....  |:.|.:|
  Fly   490 HNDVAILTLSEPVPFTREIQPICLPTSPSQQSRSYS-GQVATVAGWGSLRENGPQPSILQKVDIP 553

Human   628 V-ANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWG 691
            : .|.:....:  |:.......::|.|||..:  :|:|.|||||...:.|..  |:...||||||
  Fly   554 IWTNAECARKY--GRAAPGGIIESMICAGQAA--KDSCSGDSGGPMVINDGG--RYTQVGIVSWG 612

Human   692 IGCSRGY--GFYTKVLNYVDWIKKEME 716
            |||.:|.  |.||:|.:.:.||.|.::
  Fly   613 IGCGKGQYPGVYTRVTSLLPWIYKNIK 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839	12/58 (21%)
		Sushi	323..385	CDD:306569	13/61 (21%)
		Sushi	390..461	CDD:306569	19/78 (24%)
		Tryp_SPc	477..711	CDD:214473	75/244 (31%)
l(2)k05911	NP_723797.3	CLIP	111..174	CDD:197829
		Tryp_SPc	399..634	CDD:214473	75/244 (31%)
		Tryp_SPc	400..637	CDD:238113	76/246 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910