DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and psh

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_573297.1	Gene:	psh / 32832	FlyBaseID:	FBgn0030926	Length:	394	Species:	Drosophila melanogaster

Alignment Length:	284	Identity:	87/284 - (30%)
Similarity:	122/284 - (42%)	Gaps:	59/284 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   465 CGKPVNPVEQRQ------RIIGGQKAKMGNFPWQ-----VFTNIHGRGGGALLGDRWILTAAHTL 518
            |.|.....:||.      .|:||.....|.:|..     :......|.||:|:..|::|||||.:
  Fly   125 CKKIRERKQQRSGNQLVIHIVGGYPVDPGVYPHMAAIGYITFGTDFRCGGSLIASRFVLTAAHCV 189

Human   519 YPKEHEAQSNASLDVFLGHTNVEELMKLGNHP-----IRRVSVHPDYRQDESYNFEGDIALLELE 578
                 ...:|....|.||..|:|.    .:|.     ||.|.:||.| ....||   |||:||||
  Fly   190 -----NTDANTPAFVRLGAVNIEN----PDHSYQDIVIRSVKIHPQY-VGNKYN---DIAILELE 241

Human   579 NSVTLGPNLLPICL-------PDNDTFYDLGLMGYVSGFGVM------EEKI--AHDLRFVRLPV 628
            ..|....|:.|.||       |.|..|       :|:|:||:      ..||  ...|..|.|..
  Fly   242 RDVVETDNIRPACLHTDATDPPSNSKF-------FVAGWGVLNVTTRARSKILLRAGLELVPLDQ 299

Human   629 ANPQACENWLRGKNRM--DVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVAT--GIVS 689
            .|....|.  .|..|:  .....::.||....|..|||:|||||.. :.:.|.:..:.|  |::|
  Fly   300 CNISYAEQ--PGSIRLLKQGVIDSLLCAIDQKLIADACKGDSGGPL-IHELNVEDGMYTIMGVIS 361

Human   690 WGIGCSR-GYGFYTKVLNYVDWIK 712
            .|.||:. ..|.||:|.:|:|:|:
  Fly   362 SGFGCATVTPGLYTRVSSYLDFIE 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569
		Tryp_SPc	477..711	CDD:214473	82/263 (31%)
psh	NP_573297.1	CLIP	30..79	CDD:197829
		Tryp_SPc	143..384	CDD:214473	82/263 (31%)
		Tryp_SPc	144..387	CDD:238113	83/265 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910