DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and Lrp4

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster

Alignment Length:	174	Identity:	49/174 - (28%)
Similarity:	70/174 - (40%)	Gaps:	51/174 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   156 DLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEASGYIS 220
            |:|||...:       .|.|...|||.:|.:.|||..||.|:.|..||:|         ..|.::
  Fly   564 DIDECQYLT-------SPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKA---------LGGAMT 612

Human   221 SLEYPRSYPPDLR------CNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPY------DQLQ-IY 272
            .|...|.   |:|      ..||..|:   .||    ....:|.|.:....:      |.:: :|
  Fly   613 LLVANRW---DIRRVTLSNNRYSAIVK---GLH----NAIALDFHHRKGLMFWSDVSTDVIKMVY 667

Human   273 ANGKNIGEFC--GKQRPPDLDTSSNAV----DLLFFTDESGDSR 310
            .||..:.:..  |.:.|..:     ||    ||||:|| ||..|
  Fly   668 MNGTRVRDVIKWGLESPGGI-----AVDWIHDLLFWTD-SGTRR 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114	12/27 (44%)
		CUB	207..316	CDD:278839	29/123 (24%)
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569
		Tryp_SPc	477..711	CDD:214473
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060
		LDLa	306..340	CDD:238060
		LDLa	347..390	CDD:238060
		LDLa	397..431	CDD:238060
		LDLa	442..476	CDD:238060
		LDLa	480..521	CDD:238060
		FXa_inhibition	576..604	CDD:291342	12/27 (44%)
		LY	634..671	CDD:214531	8/43 (19%)
		NHL	<656..793	CDD:302697	17/56 (30%)
		LY	680..714	CDD:214531	13/32 (41%)
		NHL repeat	681..722	CDD:271320	12/31 (39%)
		NHL repeat	726..760	CDD:271320
		LY	761..803	CDD:214531
		NHL repeat	769..793	CDD:271320
		FXa_inhibition	882..912	CDD:291342
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910