DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG31267

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_732214.1	Gene:	CG31267 / 318651	FlyBaseID:	FBgn0051267	Length:	275	Species:	Drosophila melanogaster

Alignment Length:	264	Identity:	66/264 - (25%)
Similarity:	109/264 - (41%)	Gaps:	71/264 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   477 RIIGGQKAKMGNFPWQV-FTNIHGRG--GGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHT 538
            ||:||:::.:...|:.| ..|.:|..  .|:::.|:|::|||..|              ..|...
  Fly    44 RIVGGEESDVLAAPYLVSLQNAYGNHFCAGSIIHDQWVITAASCL--------------AGLRKN 94

Human   539 NVEELMKLGNH--------PIRRVSVHPDYRQDESYNFEGDIALLELE-----NSVTLGPNLLPI 590
            ||:.:....||        .:..:.:|.::   :|..:..||||::..     :.||....:.|:
  Fly    95 NVQVVTTTYNHWGSEGWIYSVEDIVMHCNF---DSPMYHNDIALIKTHALFDYDDVTQNITIAPL 156

Human   591 -CLPDNDTFYDLGLMGYVSGFGVMEEKIAHD----LRFVRLPVANPQACENWLRGKNRMDVFSQN 650
             .|.|.:|   |.:.||.|      .:|..|    |:.:.:....|:.|.....|...:||
  Fly   157 EDLTDGET---LTMYGYGS------TEIGGDFSWQLQQLDVTYVAPEKCNATYGGTPDLDV---- 208

Human   651 MFCAGH----PSLKQDACQGDSGGVFAVRDPNTD-RWVATGIVSWGIGCSRGYGF---YTKVLNY 707
                ||    ..:...||.||:||      |..| |....|:.:||:.|  ||||   :.::..|
  Fly   209 ----GHLCAVGKVGAGACHGDTGG------PIVDSRGRLVGVGNWGVPC--GYGFPDVFARISFY 261

Human   708 VDWI 711
            ..||
  Fly   262 YSWI 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569
		Tryp_SPc	477..711	CDD:214473	64/262 (24%)
CG31267	NP_732214.1	Tryp_SPc	44..265	CDD:214473	64/262 (24%)
CG31267	NP_732214.1	Tryp_SPc	45..268	CDD:238113	65/263 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141701
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930