DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG14780

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_569920.2	Gene:	CG14780 / 31102	FlyBaseID:	FBgn0025383	Length:	302	Species:	Drosophila melanogaster

Alignment Length:	304	Identity:	86/304 - (28%)
Similarity:	115/304 - (37%)	Gaps:	67/304 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   439 GVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQV------FTNI 497
            |::.|:....|           .|..|........|:.|||.|..||.......|      ..|.
  Fly     5 GLHGCSYILFW-----------FLLACAAADLQENQQSRIINGSVAKADETRHLVSIRLLRHDNN 58

Human   498 HGRG---GGALLGDRWILTAAHTLYPKEHEAQSNAS-LDVFLGHTNVEELMKLGNHP----IRRV 554
            .|.|   ||||:..|.:|||||.||..:.:....|| ..|.||..|..|      |.    :.:|
  Fly    59 FGSGHICGGALIAPRKVLTAAHCLYNNQRKRFRRASEFVVVLGTLNRFE------HRNGTIVSQV 117

Human   555 S----VH---PDYRQDESYNFEGDIALLELENSVTLGP------NLLPICLPDNDTFYDLGLMGY 606
            |    :|   ||..:|       |:.:|.|...:.:.|      .:.||.|....|  ..|.:..
  Fly   118 SSMAYMHTFSPDSMRD-------DVGILFLRTGLPMSPGGGVHLTVAPIQLAGQIT--PPGKLCQ 173

Human   607 VSGFGVMEE-KIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGG 670
            |:|:|..|: .:::.|....:.....|.|....|..     ....|.|||......|:|||||||
  Fly   174 VAGWGRTEQSSLSNILLTANVSTIRHQTCRMIYRSG-----LLPGMMCAGRLQGGTDSCQGDSGG 233

Human   671 VFAVRDPNTDRWVATGIVSWGIGCSR-GY-GFYTKVLNYVDWIK 712
                  |........|:||||.||:. |. |.|..|..|..||:
  Fly   234 ------PLVHEGRLVGVVSWGYGCAEPGLPGVYVDVEYYRQWIE 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569	3/21 (14%)
		Tryp_SPc	477..711	CDD:214473	78/263 (30%)
CG14780	NP_569920.2	Tryp_SPc	32..270	CDD:214473	78/263 (30%)
CG14780	NP_569920.2	Tryp_SPc	33..271	CDD:238113	78/263 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910