DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG18420

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_995715.1	Gene:	CG18420 / 2768924	FlyBaseID:	FBgn0028866	Length:	299	Species:	Drosophila melanogaster

Alignment Length:	259	Identity:	73/259 - (28%)
Similarity:	115/259 - (44%)	Gaps:	33/259 - (12%)

- Green bases have known domain annotations that are detailed below.

Human   465 CGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRG---GGALLGDRWILTAAHTLYPKEHEAQ 526
            ||.. :|::...||:.|:.|...:.||..|.:.....   ||.|:..|.:|||||...|
  Fly    31 CGTR-SPLKLGPRIVNGKVAVRNSSPWMAFLHTSSNQFICGGTLISRRLVLTAAHCFIP------ 88

Human   527 SNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPIC 591
             |.::.|.||..|.:.......|.:.|...|..|..:...|   |||||.|.::|....|:.|||
  Fly    89 -NTTIVVRLGEYNRKLKGYREEHQVNRTFQHRFYDPNTHAN---DIALLRLVSNVVYKANIRPIC 149

Human   592 LP-DNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVR-LPVANPQACENWLRGKNRMDVFS---QNM 651
            :. |....:.:..:..::|.|....:..||...:| |.::         |..::|..|.   .|.
  Fly   150 IMWDASWKHHIDSIKVLTGTGWGRTESMHDSSELRTLDIS---------RQPSKMCAFGSVLSNQ 205

Human   652 FCAGHPSLKQDACQGDSGGVFA--VRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKK 713
            ||||  :...:.|.||:||...  ||..|..|:|..||......|.|. ..:|.|::::::|::
  Fly   206 FCAG--NWNSNLCIGDTGGPVGAMVRYRNAFRFVQVGIAITNKRCQRP-SVFTDVMSHIEFIRR 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569
		Tryp_SPc	477..711	CDD:214473	69/243 (28%)
CG18420	NP_995715.1	Tryp_SPc	42..264	CDD:214473	69/243 (28%)
CG18420	NP_995715.1	Tryp_SPc	43..267	CDD:238113	69/246 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910