DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG33459

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_995855.2	Gene:	CG33459 / 2768847	FlyBaseID:	FBgn0053459	Length:	284	Species:	Drosophila melanogaster

Alignment Length:	271	Identity:	81/271 - (29%)
Similarity:	124/271 - (45%)	Gaps:	47/271 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   463 PVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGR--GGGALLGDRWILTAAHTLYPKEHEA 525
            |.||:    :..|.||.||..|.:.:.||..|.:.|.:  .||:|:...::|||||.:.|
  Fly    27 PNCGQ----IPFRMRIFGGMDAGLVSTPWMAFLHNHLQFLCGGSLITSEFVLTAAHCVMP----- 82

Human   526 QSNASLDVFLGHTNVEELMKLGN-------HPIRRVSVHPDYRQDESYNFEGDIALLELENSVTL 583
             :..:|.|.||..:....|...|       :.:.|:..||.||...:|    |||||:|..:|..
  Fly    83 -TPKNLTVRLGEYDWTRQMDSINPKHRHREYMVTRIYTHPSYRSIAAY----DIALLKLNQTVEY 142

Human   584 GPNLLPIC--LPDN--------DTFYDLGLMGYVSGFGVME-EKIAHDLRFVRLPVANPQACENW 637
            ...:.|||  ||:|        |:..|..|    :|:|..: |.::..|:...|...:...|.:
  Fly   143 TVAIRPICLVLPENFHEWYWLVDSVEDFTL----TGWGATKTEPVSQVLQSANLTQIDRGTCHD- 202

Human   638 LRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWV--ATGIVSWGIGCSRGYGF 700
             |..:.:|   ....|||  |.|..||.||||...|::..:..|::  ..||||.|.....|...
  Fly   203 -RYGHSVD---HTHICAG--SSKSFACVGDSGSPLAMKVVHNRRYIHAQVGIVSRGPKNCDGVTV 261

Human   701 YTKVLNYVDWI 711
            :|.|:::.:||
  Fly   262 FTNVVSFTEWI 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569
		Tryp_SPc	477..711	CDD:214473	75/255 (29%)
CG33459	NP_995855.2	Tryp_SPc	37..272	CDD:214473	75/255 (29%)
CG33459	NP_995855.2	Tryp_SPc	38..272	CDD:238113	74/254 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910