Protein Alignment C1R and CG42694

DIOPT Version :9

• Sequence 1: NP_001341275.1
• Gene: C1R / 715
• HGNCID: 1246
• Length: 719
• Species: Homo sapiens
• Sequence 2: NP_001188994.1
• Gene: CG42694 / 10178792
• FlyBaseID: FBgn0261584
• Length: 512
• Species: Drosophila melanogaster
• Alignment Length: 541
• Identity: 98/541 - (18%)
• Similarity: 176/541 - (32%)
• Gaps: 150/541 - (27%)

Human   269 LQIYANGKNIGEFCG---------KQRPPDLD------------------------TSSNAVDL- 299
            ||.:.|.|.:.::||         |.|.|...                        :::..:|:
  Fly    14 LQSHVNSKFLDDYCGAPISNQSITKLRQPQAGWLAHISNGTHVLCSGSLISKQFVLSAAQCIDVH 78

Human   300 --LFF---TDESGDSRGWKLRYTTEIIKCP--QPKTLDEFTIIQNLQPQYQFRDYFIATC-KQGY 356
              ||.   ...:..|..|   ||...:..|  ..|.|.....:..|.....:.|:....| ....
  Fly    79 GKLFVQLGVSNATKSPHW---YTVSNVVIPSHSGKRLQRDIGLLKLSQSVDYNDFVYPICIALNT 140

Human   357 QLIEGNQVLHSFTAVCQDDGTW-------------HRAMPRCKIKDCGQ--PRNLPNGDFRYTTT 406
            ..::..::|.:||.     ..|             ..:..|||:...|.  |:.:.....:...:
  Fly   141 NTLDMVKILQNFTT-----SAWLSKNKNPQTIVLSQLSRDRCKLNLSGNVTPKEICAASLQRNNS 200

Human   407 MGVNTYKARIQ-----------------------YYCHEP--YYKMQTRAGSRESEQGVYTCTAQ 446
            ..:::..|..|                       .:|.||  |..:....|..|:....|..|..
  Fly   201 CFIDSGSALTQPIIQGSNIVREMLFGIRGYVNGRSWCSEPAIYIDVAECVGWIETVVQQYDGTDS 265

Human   447 GIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRG---------- 501
            ......:..:.:...|...||.:                      .:|.|..|..
  Fly   266 RAVATPEVNQHLKHSLSRMGKNI----------------------LLFKNCRGNSLQSKLRARIY 308

Human   502 GGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESY 566
            |...:|..|.:|....:...:...:|..||.|.|..|    |.......::.|..||::.:|
  Fly   309 GPNYIGQGWFITHRFVITNAKDLPESAESLYVGLPGT----LRSYDEFSVQSVFKHPEFSED--- 366

Human   567 NFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRL--PVA 629
             ::.|||||.:...|.:| :|.|||:...:...:|........|..::  .|:.::.||.  .:|
  Fly   367 -YKNDIALLRVHQRVAMG-HLRPICMLLKENQQELAKSSPPISFDYVQ--TANRIQVVRKIDALA 427

Human   630 NPQACENWLRGKNRMDVFSQNMFCAGHP--SLKQDACQGDSGGVFAVRDPNTDR-W-VATGIVSW 690
            :|:.|.|.|     :.....|..|...|  :::::|.:   ||:..:|...:.: | :..||.|:
  Fly   428 DPRICTNRL-----LKTIEPNQLCVVVPPETVQKNATR---GGILGLRMMYSGKEWLILFGISSY 484

Human   691 GIGCSRGYGFYTKVLNYVDWI 711
            .   ......:|.|:.:..||
  Fly   485 S---HNDIEVFTNVMEHTQWI 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839	14/85 (16%)
		Sushi	323..385	CDD:306569	10/77 (13%)
		Sushi	390..461	CDD:306569	12/97 (12%)
		Tryp_SPc	477..711	CDD:214473	52/249 (21%)
CG42694	NP_001188994.1	Tryp_SPc	46..256	CDD:304450	30/217 (14%)
		Tryp_SPc	46..253	CDD:214473	29/214 (14%)
		Tryp_SPc	319..505	CDD:304450	48/206 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910