Protein Alignment TFRC and CG10081

DIOPT Version :9

• Sequence 1: NP_001121620.1
• Gene: TFRC / 7037
• HGNCID: 11763
• Length: 760
• Species: Homo sapiens
• Sequence 2: NP_611418.1
• Gene: CG10081 / 37226
• FlyBaseID: FBgn0034441
• Length: 875
• Species: Drosophila melanogaster
• Alignment Length: 893
• Identity: 152/893 - (17%)
• Similarity: 272/893 - (30%)
• Gaps: 364/893 - (40%)

Human    13 FGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPKRCSGSICYGTIAVIVFF 77
            |..:|.|.:        .||:.|  |.:::.|.....::.:.:...|              |:|.
  Fly   173 FDSQPTSPS--------TGDDGH--MVVSILEVLRVISSRRKSFEHP--------------IIFL 213

Human    78 LIG-------FMIGYLGYCKGVEPKTECERLAGTESPVRE---EPGEDFPAARRLYWDDLKRKLS 132
            :.|       ...|::.|.|..:.......|....|..||   :.|.:.|...::|.|..|...|
  Fly   214 INGSEENSLQASHGFIAYHKWAKNCKAVINLDAAGSGGRELMFQSGPNNPWLVKIYKDGAKHYFS 278

Human   133 EKLDSTDF-TGTI---------------------KLLNENSY---------VPREAGSQKDENLA 166
            ..:....| ||.:                     :.:|...|         :||.|.....:||.
  Fly   279 TTMAEEIFQTGLVPSYTDFDIFVEYGNLIGLDIGQCINGFVYHTKYDRIDVIPRAALQNTGDNLL 343

Human   167 LYVENQFREFKLSKVWRDQHFVKIQVKDSAQN---SVIIVDKNGRLVYLVENPGGYVAYSKAATV 228
            ..|:.      ||..        .:::|.:.|   :.|..|..|  :||       ::||
  Fly   344 GLVQT------LSNA--------SELRDLSANPTGNTIFFDVLG--LYL-------ISYS----- 380

Human   229 TGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVA-NAESLNAIGVLIYMDQ------- 285
                  |:.|.|.:    |.....:|:::....:..|||.: ::|.:.:..:|:.:.|
  Fly   381 ------ADVGVKLN----YAVAAAAIILIYISLLRIAEKSSVSSEQILSTFILVLVVQLIAFVLA 435

Human   286 TKFPIVNA--------ELSFFGHAHLGTGDPYTPG-----FPSFNHTQFPPSRSSGLPNIPVQTI 337
            ...|::.|        .||:|....|..|....|.     .||:.:.:        |.|....:.
  Fly   436 LALPLLVAYGLDKYGLSLSYFATPSLLIGLYICPSLLGLTLPSYIYLK--------LANTEKVSF 492

Human   338 SRAAAEKLFG------------NMEGDCPSDWKTDSTCRMVTSESKNVKLTV-------SNVLKE 383
            ::.....|.|            |..|...:...|.:....|...:.|:..|:       :.:||.
  Fly   493 AQQVQLALHGHAAVLSILCIAINYYGLRTTYVITWTLAFYVIPLAFNLLTTLHDRGYSWTGILKI 557

Human   384 IKI--------------------LNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLK 428
            :::                    :..|||   ...||  :::|          |.:.:||.|.:.
  Fly   558 VQVAPFMYNSYLFYCFIVILTPMMGRFGV---DTNPD--LIIG----------ALTALGTILSMG 607

Human   429 LAQMFSDMVLKDGF-------------------------QPSRSI----------IFASWSAGDF 458
            ...:..:|..:.||                         :|..::          ||..:.
  Fly   608 FLILLVNMSRRSGFVLIGLLAVTAAGVYIASSTDIGFPYRPKTNVQRVPYLQVRRIFYEYD---- 668

Human   459 GSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYT------LIEKTMQNVKHPV 517
            |:|...|  .|||.:|.         |:..|         :|||.:      |:..|....|:.:
  Fly   669 GTVSKDE--SGYLFNLQ---------DRRGL---------TPLLESNVDLTGLVNMTSDCAKYMM 713

Human   518 TGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPE 582
            .|..|| |..|...:|                                  |||        .:|.
  Fly   714 CGMPLY-DHRWVEAME----------------------------------TTM--------WLPR 735

Human   583 LNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARG 647
            .|.|...|..:                               |.|....:...|.::|:.:
  Fly   736 KNPVWTPAEPI-------------------------------LKQLNKTVLADGQTVQFEF---- 765

Human   648 DFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPAL 712
                   .|||    ::.|..|:..  |:.|:...:.||..|::....|: |:::..|
  Fly   766 -------ELTT----SDHTSIFISP--NEDVIISNWSFLKEYLTTNSPPY-HIYYSFG------- 809

Human   713 LENLKLR-----KQNNGAFNETLFRNQLALATWTIQG------AANAL 749
            ::|..||     |:.:|.:...||:..:......::|      .||:|
  Fly   810 IDNTPLRFHIELKKADGVYTVPLFQMGIGAHYMHVKGDDESIRLANSL 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFRC	NP_001121620.1	Mediates interaction with SH3BP4. /evidence=ECO:0000269|PubMed:16325581	1..67		9/53 (17%)
		Endocytosis signal. /evidence=ECO:0000269|PubMed:2298808	20..23		0/2 (0%)
		Stop-transfer sequence. /evidence=ECO:0000303|PubMed:6090955	58..61		1/2 (50%)
		PA_TfR	201..377	CDD:239043	37/208 (18%)
		M28_TfR	385..610	CDD:193572	44/285 (15%)
		Ligand-binding	569..760		34/192 (18%)
		TFR_dimer	642..750	CDD:282153	24/119 (20%)
		Cell attachment site, required for binding to transferrin	646..648		0/1 (0%)
CG10081	NP_611418.1	M28_Fxna_like	72..379	CDD:193497	45/252 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900