DRSC/TRiP Functional Genomics Resources

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Protein Alignment TFRC and CG9416

DIOPT Version :9

Sequence 1:NP_001121620.1 Gene:TFRC / 7037 HGNCID:11763 Length:760 Species:Homo sapiens
Sequence 2:NP_001261088.1 Gene:CG9416 / 37223 FlyBaseID:FBgn0034438 Length:861 Species:Drosophila melanogaster


Alignment Length:328 Identity:62/328 - (18%)
Similarity:126/328 - (38%) Gaps:66/328 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   309 YTPGFPSFNHT--------------QFPPSRSSG----LPNIPVQTISRAAAEKL---FGNME-G 351
            |....|||:..              ||...|:..    |..|..:.:..||.|::   |...| |
  Fly    34 YLVVIPSFHRMPQLKTLEDERQQPGQFIGERAENTLLRLSKIGPKVVGSAANEQVAVQFLLSEIG 98

Human   352 DCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFV--------EPDHYVVVGAQ 408
            |...|.:||     :....|:|::...|.|. ..::|::..|:..|        ..:..:::.:.
  Fly    99 DIIDDARTD-----LYDIEKDVQVASGNYLL-WSMVNVYQSIQNVVVKLSPKNATSEAALLINSH 157

Human   409 RDA--WGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYL 471
            .|:  ...||..:|:...::|::.:    ::.|.....:.|::|....|.:....|:..::..:.
  Fly   158 FDSVPGSSGAGDAGMMCVIMLEVLR----VITKYETPLTYSVVFLFNGAEENPLQGSHAFITQHP 218

Human   472 SSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHP---VTGQFLYQDSNWASKVE 533
            .:.:::|  .||||.|..|.......:.|....|::...:|:.||   ..|:.|:|:....|:.:
  Fly   219 WAQNIRA--VINLDSAGSGGREILFQSGPDHPWLMKYYGKNIVHPFASTIGEELFQNGFVPSETD 281

Human   534 KLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFV 598
            ...       |..|..||.:.           :..|::.| ....:....|.:.|...::.|:.:
  Fly   282 YRV-------FRDYGHIPGLD-----------MAQTLNGY-VYHTKYDRFNLIPRRTYQLTGENI 327

Human   599 IKL 601
            :.|
  Fly   328 LAL 330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TFRCNP_001121620.1 Mediates interaction with SH3BP4. /evidence=ECO:0000269|PubMed:16325581 1..67
Endocytosis signal. /evidence=ECO:0000269|PubMed:2298808 20..23
Stop-transfer sequence. /evidence=ECO:0000303|PubMed:6090955 58..61
PA_TfR 201..377 CDD:239043 21/89 (24%)
M28_TfR 385..610 CDD:193572 39/230 (17%)
Ligand-binding 569..760 6/33 (18%)
TFR_dimer 642..750 CDD:282153
Cell attachment site, required for binding to transferrin 646..648
CG9416NP_001261088.1 M28_Fxna_like 57..364 CDD:193497 58/305 (19%)
MFS 423..>624 CDD:304372
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2234
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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