DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TFRC and CG9416

DIOPT Version :9

Sequence 1:	NP_001121620.1	Gene:	TFRC / 7037	HGNCID:	11763	Length:	760	Species:	Homo sapiens
Sequence 2:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster

Alignment Length:	328	Identity:	62/328 - (18%)
Similarity:	126/328 - (38%)	Gaps:	66/328 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   309 YTPGFPSFNHT--------------QFPPSRSSG----LPNIPVQTISRAAAEKL---FGNME-G 351
            |....|||:..              ||...|:..    |..|..:.:..||.|::   |...| |
  Fly    34 YLVVIPSFHRMPQLKTLEDERQQPGQFIGERAENTLLRLSKIGPKVVGSAANEQVAVQFLLSEIG 98

Human   352 DCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFV--------EPDHYVVVGAQ 408
            |...|.:||     :....|:|::...|.|. ..::|::..|:..|        ..:..:::.:.
  Fly    99 DIIDDARTD-----LYDIEKDVQVASGNYLL-WSMVNVYQSIQNVVVKLSPKNATSEAALLINSH 157

Human   409 RDA--WGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYL 471
            .|:  ...||..:|:...::|::.:    ::.|.....:.|::|....|.:....|:..::..:.
  Fly   158 FDSVPGSSGAGDAGMMCVIMLEVLR----VITKYETPLTYSVVFLFNGAEENPLQGSHAFITQHP 218

Human   472 SSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHP---VTGQFLYQDSNWASKVE 533
            .:.:::|  .||||.|..|.......:.|....|::...:|:.||   ..|:.|:|:....|:.:
  Fly   219 WAQNIRA--VINLDSAGSGGREILFQSGPDHPWLMKYYGKNIVHPFASTIGEELFQNGFVPSETD 281

Human   534 KLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFV 598
            ...       |..|..||.:.           :..|::.| ....:....|.:.|...::.|:.:
  Fly   282 YRV-------FRDYGHIPGLD-----------MAQTLNGY-VYHTKYDRFNLIPRRTYQLTGENI 327

Human   599 IKL 601
            :.|
  Fly   328 LAL 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFRC	NP_001121620.1	Mediates interaction with SH3BP4. /evidence=ECO:0000269\|PubMed:16325581	1..67
		Endocytosis signal. /evidence=ECO:0000269\|PubMed:2298808	20..23
		Stop-transfer sequence. /evidence=ECO:0000303\|PubMed:6090955	58..61
		PA_TfR	201..377	CDD:239043	21/89 (24%)
		M28_TfR	385..610	CDD:193572	39/230 (17%)
		Ligand-binding	569..760		6/33 (18%)
		TFR_dimer	642..750	CDD:282153
		Cell attachment site, required for binding to transferrin	646..648
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	58/305 (19%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900