Protein Alignment: TFRC and CG9416

• Sequence 1: NP_001121620.1
• Gene: TFRC
• HGNCID: 11763
• Length: 760
• Species: Homo sapiens
• Sequence 2: NP_001261088.1
• Gene: CG9416
• FlyBaseID: FBgn0034438
• Length: 861
• Species: Drosophila melanogaster
• Alignment Length: 329
• Identity: 61/330 (18%)
• Similarity: 125/330 (38%)
• Gaps: 68/330 (21%)

Human   309 YTPGFPSFNHT--------------QFPPSRSSG----LPNIPVQTISRAAAEK-----LFGNME 350
            |....|||:..              ||...|:..    |..|..:.:..||.|:     |...:
  Fly    34 YLVVIPSFHRMPQLKTLEDERQQPGQFIGERAENTLLRLSKIGPKVVGSAANEQVAVQFLLSEI- 97

Human   351 GDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFV--------EPDHYVVVGA 407
            ||...|.:||     :....|:|::...|.|. ..::|::..|:..|        ..:..:::.:
  Fly    98 GDIIDDARTD-----LYDIEKDVQVASGNYLL-WSMVNVYQSIQNVVVKLSPKNATSEAALLINS 156

Human   408 QRDA--WGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGY 470
            ..|:  ...||..:|:...::|::.:    ::.|.....:.|::|....|.:....|:..::..:
  Fly   157 HFDSVPGSSGAGDAGMMCVIMLEVLR----VITKYETPLTYSVVFLFNGAEENPLQGSHAFITQH 217

Human   471 LSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHP---VTGQFLYQDSNWASKV 532
            ..:.:::|  .||||.|..|.......:.|....|::...:|:.||   ..|:.|:|:....|:.
  Fly   218 PWAQNIRA--VINLDSAGSGGREILFQSGPDHPWLMKYYGKNIVHPFASTIGEELFQNGFVPSET 280

Human   533 EKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQF 597
            :...       |..|..||.:.           :..|::.| ....:....|.:.|...::.|:.
  Fly   281 DYRV-------FRDYGHIPGLD-----------MAQTLNGY-VYHTKYDRFNLIPRRTYQLTGEN 326

Human   598 VIKL 601
            ::.|
  Fly   327 ILAL 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFRC	NP_001121620.1	Mediates interaction with SH3BP4. {ECO:0000269|PubMed:16325581}	1..67
		Endocytosis signal	20..23
		Stop-transfer sequence	58..61
		PA_TfR	201..377	CDD:239043	20/91 (22%)
		M28_TfR	385..610	CDD:193572	39/231 (17%)
		Ligand-binding	569..760		6/34 (18%)
		TFR_dimer	642..750	CDD:282153
		Cell attachment site, required for binding to transferrin	646..648
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	57/307 (19%)
		MFS	423..>624	CDD:304372

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900