Protein Alignment TFRC and CG10051

DIOPT Version :10

• Sequence 1: NP_003225.2
• Gene: TFRC / 7037
• HGNCID: 11763
• Length: 760
• Species: Homo sapiens
• Sequence 2: NP_611414.1
• Gene: CG10051 / 37222
• FlyBaseID: FBgn0034437
• Length: 866
• Species: Drosophila melanogaster
• Alignment Length: 576
• Identity: 124/576 - (21%)
• Similarity: 185/576 - (32%)
• Gaps: 188/576 - (32%)

Human   151 SYVPREAGSQKDE-NLALY---VENQFRE------------FKLSKVWRDQHFVKIQVKDSAQNS 199
            :::.||....||| .|.||   |:.|:..            ..||.|     .|||..|.|...:
  Fly    96 NFLLREIQKIKDEARLDLYDIEVDTQYSSGAFHLWGMTISYTNLSNV-----VVKISQKSSDNEN 155

Human   200 VIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGT----KKDFEDLYTPV----NGSIVI 256
            .::|  |......|:.|        ||...|.:|.....|    .:....|..||    ||:...
  Fly   156 YLLV--NSHYDSEVQTP--------AAGDDGVMVVVMLETLRVISRSERTLTHPVVFLFNGAEEA 210

Human   257 VRAGKITF---------AEKVANAESLNAIG--VLI------------YMDQTKFPIVN--AELS 296
            ...|...|         .:.:.|.:|..|.|  ||.            |......|...  || .
  Fly   211 CMLGSHGFITQHKWSKNCKALVNLDSTGAGGREVLFQTGPNHPWLAKYYQASVPHPYAQTLAE-E 274

Human   297 FFGH-----------------------AHLGTGDPYTPGFPSFNHTQFPPSRSSG---------L 329
            .|.|                       |.:..|..|...|.:|.:.::...:|:|         |
  Fly   275 LFQHNFIPSDTDFRIFRDYGGVPGLDMASVMNGYVYHTEFDNFKNVEYGTYQSTGENVLPLIWAL 339

Human   330 PNIPVQTISRAAAEK---LFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFG 391
            .|.| :..:..|.||   ::.:..|     |     ..|..:||.::.:   ||:..:......|
  Fly   340 ANAP-ELDNTTAYEKGHTVYYDFLG-----W-----FMMTYTESVSIAI---NVVVSVAAFICIG 390

Human   392 VIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDM---------------VLKDG 441
            .....:..|:           |..|.|     |::|:.|.:|...               |...|
  Fly   391 TSVYIMTLDN-----------GADAPK-----AVVLRFAIIFLVQAGTLFVACGLTLLVAVFMQG 439

Human   442 FQPSRSIIFASWSAGDFGSVGATEWLE-GYLSSLHL---KAFTYINLDKAVLGTSNFKVSASPLL 502
            ...:.|..:..|.|  ||....|.:.. |.|.:.::   |..|.:.||:.:   :.|..:...||
  Fly   440 VGLAESWYYGKWMA--FGLYFCTLFFAFGILPATYIGFTKRKTNMKLDQTI---ACFMHAQCILL 499

Human   503 YTL-IEKTMQNVK---HPVTGQFLYQDSNWASKVEKLTLDNAAF----------PFLAYSGI--- 550
            ..| |..|:..::   .|:.|.|.|..|.....|.||||..:.|          ||..|:.|
  Fly   500 ALLCIIMTIMGIRSSYFPMVGIFFYAISVLVQIVLKLTLKKSYFVTVHLLFQVLPFFFYTYICYA 564

Human   551 PAVSFCFCEDTDYPYLGTTMDTYKELIERIPELN---KVARAAAEVAGQFVIKLTH 603
            ..|:|...|..|.|             |..|::.   .:...|...|| |||.:.|
  Fly   565 TLVTFVPMEGRDGP-------------ESSPDIMISVFIIATAINYAG-FVIPIMH 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFRC	NP_003225.2	Mediates interaction with SH3BP4. /evidence=ECO:0000269|PubMed:16325581	1..67
		Endocytosis signal. /evidence=ECO:0000269|PubMed:2298808	20..23
		Stop-transfer sequence. /evidence=ECO:0000303|PubMed:6090955	58..61
		PA_TfR	201..377	CDD:239043	46/243 (19%)
		M28_TfR	364..610	CDD:349946	63/279 (23%)
		Ligand-binding	569..760		9/38 (24%)
		TFR_dimer	637..750	CDD:461238
		Cell attachment site, required for binding to transferrin	646..648
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:349872	62/299 (21%)
		MATE_like	361..>604	CDD:447704	64/290 (22%)