Protein Alignment TFRC and CG11961

DIOPT Version :10

• Sequence 1: NP_003225.2
• Gene: TFRC / 7037
• HGNCID: 11763
• Length: 760
• Species: Homo sapiens
• Sequence 2: NP_725876.1
• Gene: CG11961 / 37221
• FlyBaseID: FBgn0034436
• Length: 891
• Species: Drosophila melanogaster
• Alignment Length: 276
• Identity: 57/276 - (20%)
• Similarity: 104/276 - (37%)
• Gaps: 68/276 - (24%)

Human   372 NVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDA--WGPGAAKSGVGTALLLKLAQMF- 433
            |:..::.|::.:|...|        .....|::|.:..|:  .||||...|...|.::::.::.
  Fly   160 NMYQSIQNIVVKISPKN--------TNSTTYLLVNSHYDSVPAGPGAGDDGSMVATMMEVLRVLA 216

Human   434 -SDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVS 497
             ||..||:      .::|....|.:.....:..::..:..:.:.||.  ||||....|.......
  Fly   217 KSDKPLKN------PVVFLFNGAEENPLQASHAFITQHKWAKYCKAL--INLDSCGNGGREILFQ 273

Human   498 ASPLLYTLIEKTMQNVKHP---VTGQFLYQDSNWASKVE-KLTLDNAAFPFLAYSGIPAVSFCFC 558
            :.|....|::...:.:|||   ..|:.|:|.:...|..: ::..|:.:.|.|
  Fly   274 SGPNHPWLMKNYRRAIKHPYASTMGEELFQHNFIPSDTDFRIFRDHGSVPGL------------- 325

Human   559 EDTDYPYLG-------------------TTMDTYKELIERI---PELNKVARAAA------EVAG 595
             |..|.|.|                   .|.|....|:.:|   ||:...|:.|.      :|.|
  Fly   326 -DMAYTYNGFVYHTRHDKAEIFPRGSFQHTGDNLLALVRQIANSPEIENSAKYAKGHTIYFDVMG 389

Human   596 QFVI--KLTHDVELNL 609
            .|::  ..|..|.||:
  Fly   390 WFLVFYTETEGVILNV 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFRC	NP_003225.2	Mediates interaction with SH3BP4. /evidence=ECO:0000269|PubMed:16325581	1..67
		Endocytosis signal. /evidence=ECO:0000269|PubMed:2298808	20..23
		Stop-transfer sequence. /evidence=ECO:0000303|PubMed:6090955	58..61
		PA_TfR	201..377	CDD:239043	1/4 (25%)
		M28_TfR	364..610	CDD:349946	57/276 (21%)
		Ligand-binding	569..760		15/52 (29%)
		TFR_dimer	637..750	CDD:461238
		Cell attachment site, required for binding to transferrin	646..648
CG11961	NP_725876.1	M28_Fxna_like	91..395	CDD:349872	53/264 (20%)
		MFS	<539..>658	CDD:475125