DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TFRC and CG11961

DIOPT Version :9

Sequence 1:	NP_001121620.1	Gene:	TFRC / 7037	HGNCID:	11763	Length:	760	Species:	Homo sapiens
Sequence 2:	NP_001246418.1	Gene:	CG11961 / 37221	FlyBaseID:	FBgn0034436	Length:	891	Species:	Drosophila melanogaster

Alignment Length:	276	Identity:	57/276 - (20%)
Similarity:	104/276 - (37%)	Gaps:	68/276 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   372 NVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDA--WGPGAAKSGVGTALLLKLAQMF- 433
            |:..::.|::.:|...|        .....|::|.:..|:  .||||...|...|.::::.::.
  Fly   160 NMYQSIQNIVVKISPKN--------TNSTTYLLVNSHYDSVPAGPGAGDDGSMVATMMEVLRVLA 216

Human   434 -SDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVS 497
             ||..||:      .::|....|.:.....:..::..:..:.:.||.  ||||....|.......
  Fly   217 KSDKPLKN------PVVFLFNGAEENPLQASHAFITQHKWAKYCKAL--INLDSCGNGGREILFQ 273

Human   498 ASPLLYTLIEKTMQNVKHP---VTGQFLYQDSNWASKVE-KLTLDNAAFPFLAYSGIPAVSFCFC 558
            :.|....|::...:.:|||   ..|:.|:|.:...|..: ::..|:.:.|.|
  Fly   274 SGPNHPWLMKNYRRAIKHPYASTMGEELFQHNFIPSDTDFRIFRDHGSVPGL------------- 325

Human   559 EDTDYPYLG-------------------TTMDTYKELIERI---PELNKVARAAA------EVAG 595
             |..|.|.|                   .|.|....|:.:|   ||:...|:.|.      :|.|
  Fly   326 -DMAYTYNGFVYHTRHDKAEIFPRGSFQHTGDNLLALVRQIANSPEIENSAKYAKGHTIYFDVMG 389

Human   596 QFVI--KLTHDVELNL 609
            .|::  ..|..|.||:
  Fly   390 WFLVFYTETEGVILNV 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFRC	NP_001121620.1	Mediates interaction with SH3BP4. /evidence=ECO:0000269\|PubMed:16325581	1..67
		Endocytosis signal. /evidence=ECO:0000269\|PubMed:2298808	20..23
		Stop-transfer sequence. /evidence=ECO:0000303\|PubMed:6090955	58..61
		PA_TfR	201..377	CDD:239043	1/4 (25%)
		M28_TfR	385..610	CDD:193572	54/263 (21%)
		Ligand-binding	569..760		15/52 (29%)
		TFR_dimer	642..750	CDD:282153
		Cell attachment site, required for binding to transferrin	646..648
CG11961	NP_001246418.1	M28_Fxna_like	91..395	CDD:193497	53/264 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900