DRSC/TRiP Functional Genomics Resources

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Protein Alignment: TFRC and CG33012

Sequence 1:NP_001121620.1 Gene:TFRC HGNCID:11763 Length:760 Species:Homo sapiens
Sequence 2:NP_788335.2 Gene:CG33012 FlyBaseID:FBgn0053012 Length:912 Species:Drosophila melanogaster

Alignment Length:345 Identity:68/346 (20%)
Similarity:123/346 (36%) Gaps:78/346 (23%)


Human   313 FPSFNH--TQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCP---SDWKTD-STCRMVTSESK 371
            :|.|||  |.......:.||.    |.....||.:...::...|   .|:.|: .....:..|..
  Fly    84 YPLFNHLPTGVKIEEEANLPG----TFVAQRAESILIRLDLMGPKIAGDYVTEVEMVEFLLGEIS 144

Human   372 NVKLTVSNVLKEIKI--------------LNIFGVIKGFV--------EPDHYVVVGAQRD---- 410
            .|:..:.|.|.::::              :|::..|:..|        ....|::|.:..|    
  Fly   145 KVRDEMRNDLYDMEVDVQRSSGSFLHWQMINMYQGIQNVVVKLSSKSSNSTSYLLVNSHYDSKPS 209

Human   411 AWGPGAAKSGVGTAL-LLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSL 474
            :.|.|.|:..|.|.| .|:|.....:..|       ..|:|....|.:....|:..::..:..|.
  Fly   210 SVGTGDAELMVVTMLETLRLMATSEETFL-------HPIVFLFNGAEEQPFHGSHSFISNHRWSA 267

Human   475 HLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHP---VTGQFLYQDSNWASKVEKLT 536
            :.||.  :|||.|..|.........|....|:::..::.|||   ...:.::|       .:.:.
  Fly   268 NCKAL--VNLDSAGAGGREILFQGGPNHPWLMKQYKKSAKHPFATTMAEEIFQ-------ADLIP 323

Human   537 LDNAAFPFLAYSGIPAVSFCFCEDTDYPYLG----TTMDTYKELIERIPELNKVARAAAEVAGQF 597
            .|.....|..:..:|.:....|      |.|    |..|.||          .::|.|.:..|..
  Fly   324 SDTDFRIFRDFGPVPGLDMAGC------YNGFVYHTKFDRYK----------VISRGALQNTGDN 372

Human   598 VIKLTHDVELNLDYERYNSQ 617
            |:.|...:. |.: |.|:::
  Fly   373 VLSLVRSIS-NAE-EMYDTE 390

Known Domains:


GeneSequenceDomainRegion External IDIdentity
TFRCNP_001121620.1 Mediates interaction with SH3BP4. {ECO:0000269|PubMed:16325581} 1..67
Endocytosis signal 20..23
Stop-transfer sequence 58..61
PA_TfR 201..377 CDD:239043 15/70 (21%)
M28_TfR 385..610 CDD:193572 49/259 (19%)
Ligand-binding 569..760 11/50 (22%)
TFR_dimer 642..750 CDD:282153
Cell attachment site, required for binding to transferrin 646..648
CG33012NP_788335.2 M28_Fxna_like 103..410 CDD:193497 62/327 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 1 0.900 E1_COG2234
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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