DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TFRC and CG30049

DIOPT Version :9

Sequence 1:	NP_001121620.1	Gene:	TFRC / 7037	HGNCID:	11763	Length:	760	Species:	Homo sapiens
Sequence 2:	NP_725142.3	Gene:	CG30049 / 246416	FlyBaseID:	FBgn0050049	Length:	878	Species:	Drosophila melanogaster

Alignment Length:	365	Identity:	66/365 - (18%)
Similarity:	114/365 - (31%)	Gaps:	103/365 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   307 DPYTPGFPSFNHTQFPPSRSSGL--------PNIPVQTISRAA--------AEKLFGNMEGDC-- 353
            :|..||       ||...|:..:        |.:...|.:...        .||:...|.||.
  Fly    67 EPLKPG-------QFVGERAQKILYELDRIGPKVVGSTANEVTTVAFLLNEVEKIRSEMRGDLFH 124

Human   354 -------PSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDA 411
                   |:......|...:....:||.:.:|....               ....|:::.:..|.
  Fly   125 LEVDVQQPTGSYVVGTMTSIYQGIQNVVVKLSTASS---------------NSSSYLLINSHFDT 174

Human   412 --WGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSA------GDFGSVGATEWLE 468
              ..|||...|....::|::.:..|  :.:..|.  ..|:|....|      ...|.:...:|
  Fly   175 KPGSPGAGDDGTMVVVMLEVLRQMS--ISESEFM--HPIVFLFNGAEENPLQASHGFITQHKW-- 233

Human   469 GYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVE 533
                :.:.||  .|||:....|..:....:.|....|::...|:.|||..       |..|.::.
  Fly   234 ----APNCKA--VINLEVGGNGGRDILFQSGPNNPWLVKYYKQHSKHPFA-------STLAEEIF 285

Human   534 K---LTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTY--------KELIERIPELNKVA 587
            :   |..|.....|..|..||.:......: .|.| .|..|::        :...|.|..|.:..
  Fly   286 QFGILPSDTDFRIFRDYGNIPGLDIAQFSN-GYVY-HTAFDSFDVVPGRAVQNTGENILSLVRAL 348

Human   588 RAAAEV----------------AGQFVIKLTHDVELNLDY 611
            ..|:|:                .|.|.:..|.:..:.|:|
  Fly   349 SNASELYNTNEHSAGHAVFFDFLGLFFVTYTENTGIILNY 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFRC	NP_001121620.1	Mediates interaction with SH3BP4. /evidence=ECO:0000269\|PubMed:16325581	1..67
		Endocytosis signal. /evidence=ECO:0000269\|PubMed:2298808	20..23
		Stop-transfer sequence. /evidence=ECO:0000303\|PubMed:6090955	58..61
		PA_TfR	201..377	CDD:239043	17/94 (18%)
		M28_TfR	385..610	CDD:193572	46/259 (18%)
		Ligand-binding	569..760		11/67 (16%)
		TFR_dimer	642..750	CDD:282153
		Cell attachment site, required for binding to transferrin	646..648
CG30049	NP_725142.3	M28_Fxna_like	71..378	CDD:193497	62/349 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900