Protein Alignment TFRC and CG30047

DIOPT Version :10

• Sequence 1: NP_003225.2
• Gene: TFRC / 7037
• HGNCID: 11763
• Length: 760
• Species: Homo sapiens
• Sequence 2: NP_725141.1
• Gene: CG30047 / 246414
• FlyBaseID: FBgn0050047
• Length: 879
• Species: Drosophila melanogaster
• Alignment Length: 185
• Identity: 37/185 - (20%)
• Similarity: 72/185 - (38%)
• Gaps: 40/185 - (21%)

Human   361 STCRMVTSESKNVKLTVSNVLKEIKI--------------LNIF-GVIKGFVE-------PDHYV 403
            :|...:..|.:|::..:.:.|.|:::              :|:: ||....|:       ...|:
  Fly   103 TTVAFLEEEVENIRAAMRSDLYELQLDVQHPSGAYMHWQMVNMYQGVTNVVVKISSRSSNSSSYL 167

Human   404 VVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQP-SRSIIFASWSA------GDFGSV 461
            :|.:..|: .|.:..||....:::.:.::...:.:.|  .| ...|:|....|      ...|.:
  Fly   168 LVNSHFDS-KPSSPGSGDDGTMVVVMLEVLRQVAISD--TPFEHPIVFLFNGAEENPLEASHGFI 229

Human   462 GATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHP 516
            ...:| .|...:|       |||:.|..|..:....:.|....||:...||.|||
  Fly   230 TQHKW-AGNCKAL-------INLEVAGSGGRDLLFQSGPNNPWLIKYYYQNAKHP 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFRC	NP_003225.2	Mediates interaction with SH3BP4. /evidence=ECO:0000269|PubMed:16325581	1..67
		Endocytosis signal. /evidence=ECO:0000269|PubMed:2298808	20..23
		Stop-transfer sequence. /evidence=ECO:0000303|PubMed:6090955	58..61
		PA_TfR	201..377	CDD:239043	3/15 (20%)
		M28_TfR	364..610	CDD:349946	36/182 (20%)
		Ligand-binding	569..760
		TFR_dimer	637..750	CDD:461238
		Cell attachment site, required for binding to transferrin	646..648
CG30047	NP_725141.1	M28_Fxna_like	72..379	CDD:349872	37/185 (20%)