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Protein Alignment TFRC and CG30047

DIOPT Version :9

Sequence 1:	NP_003225.2	Gene:	TFRC / 7037	HGNCID:	11763	Length:	760	Species:	Homo sapiens
Sequence 2:	NP_725141.1	Gene:	CG30047 / 246414	FlyBaseID:	FBgn0050047	Length:	879	Species:	Drosophila melanogaster

Alignment Length:	185	Identity:	37/185 - (20%)
Similarity:	72/185 - (38%)	Gaps:	40/185 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   361 STCRMVTSESKNVKLTVSNVLKEIKI--------------LNIF-GVIKGFVE-------PDHYV 403
            :|...:..|.:|::..:.:.|.|:::              :|:: ||....|:       ...|:
  Fly   103 TTVAFLEEEVENIRAAMRSDLYELQLDVQHPSGAYMHWQMVNMYQGVTNVVVKISSRSSNSSSYL 167

Human   404 VVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQP-SRSIIFASWSA------GDFGSV 461
            :|.:..|: .|.:..||....:::.:.::...:.:.|  .| ...|:|....|      ...|.:
  Fly   168 LVNSHFDS-KPSSPGSGDDGTMVVVMLEVLRQVAISD--TPFEHPIVFLFNGAEENPLEASHGFI 229

Human   462 GATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHP 516
            ...:| .|...:|       |||:.|..|..:....:.|....||:...||.|||
  Fly   230 TQHKW-AGNCKAL-------INLEVAGSGGRDLLFQSGPNNPWLIKYYYQNAKHP 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFRC	NP_003225.2	Mediates interaction with SH3BP4. /evidence=ECO:0000269\|PubMed:16325581	1..67
		Endocytosis signal. /evidence=ECO:0000269\|PubMed:2298808	20..23
		Stop-transfer sequence. /evidence=ECO:0000303\|PubMed:6090955	58..61
		PA_TfR	201..377	CDD:239043	3/15 (20%)
		M28_TfR	364..610	CDD:349946	36/182 (20%)
		Ligand-binding	569..760
		TFR_dimer	637..750	CDD:461238
		Cell attachment site, required for binding to transferrin	646..648
CG30047	NP_725141.1	M28_Fxna_like	72..379	CDD:349872	37/185 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Software error:

Can't use an undefined value as an ARRAY reference at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 1034.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-
Hieranoid	0	0.000	Not matched by this tool.