DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TCF12 and Fer3

DIOPT Version :9

Sequence 1:	XP_011520261.1	Gene:	TCF12 / 6938	HGNCID:	11623	Length:	718	Species:	Homo sapiens
Sequence 2:	NP_524322.1	Gene:	Fer3 / 41411	FlyBaseID:	FBgn0037937	Length:	195	Species:	Drosophila melanogaster

Alignment Length:	180	Identity:	40/180 - (22%)
Similarity:	76/180 - (42%)	Gaps:	43/180 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   149 DLGLGSPAQLSS--SGKPGTAYYSFSATSSRRRPLHDSAALDPLQAKKVRKVPPGLPSSVYAPSP 211
            ||.|...:|::.  ..:|.|...:..::||.::.....|::...:|..:|:     ...::..:.
  Fly    45 DLSLWQRSQVTPLVPQRPSTNGRANGSSSSSKKTRRRVASMAQRRAANIRE-----RRRMFNLNE 104

Human   212 NSDDFNRESPSYPSPKP----PTSMFASTF--FMQDGTHNSSDLWSSSNGMSQPGFGGILGT-ST 269
            ..|...|:.|::...|.    .|...|.|:  ||       ::|.|              || |.
  Fly   105 AFDKLRRKVPTFAYEKRLSRIETLRLAITYIGFM-------AELLS--------------GTPSN 148

Human   270 SHMSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPY 319
            ||.|:|..||:::.|.:.  ||.::.|..::    |.:::.|  ..:|||
  Fly   149 SHKSRSDVYGSMNGHHQA--PPPAIHPHHLH----PAAAYQR--DFASPY 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TCF12	XP_011520261.1	CytochromB561_N	287..>460	CDD:286826	8/33 (24%)
TCF12	XP_011520261.1	HLH	619..672	CDD:197674
Fer3	NP_524322.1	HLH	87..135	CDD:278439	9/52 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910