DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atp8b3 and CG33298

DIOPT Version :9

Sequence 1:	NP_080370.2	Gene:	Atp8b3 / 67331	MGIID:	1914581	Length:	1335	Species:	Mus musculus
Sequence 2:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1347	Identity:	402/1347 - (29%)
Similarity:	634/1347 - (47%)	Gaps:	293/1347 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 NLEDKDTEFTWEVKANDRTYHKQFKKKGFLCWRQKKYKSNAIHTAKYNIFSFLPLNLYEQFHRMS 73
            |..||..|.::.....:.|...:..|:..   ...::..|.|.|.||.:.||:|.||.|||||::
  Fly   217 NTGDKFEERSYRTVVPNHTVPPKTPKRDH---PNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVA 278

Mouse    74 NLYFLFIIILQGIPEISTLPWFTLFAPLVCLFVIRATRDLVDDIGRHRSDKIINNRPCQILRGKS 138
            ||||:||::|..:||||.........|::.:..:.|.:||.:|..|..|||.|||..|::..|::
  Fly   279 NLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGET 343

Mouse   139 FLWK--KWKNLCVGDVVCLSKDSIVPADLLLLASTEPSSLCYVETADIDGETNLKFRQALTVTHH 201
            ..:|  ||:.|.|||:|.||.:..||||:|||.:::|..:||::|.|:|||||||.|:.:. ...
  Fly   344 ERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVR-GFE 407

Mouse   202 ELTSPKKMASFQGTVTCEEPNSRMHHFVGSL-EWNSRKYPLDIGNLLLRGCKIRNTDTCYGLVIY 265
            |:.|....:.|...|..:.|.::::.|.|:| .....:.|:....||||..:::|||...|:|:|
  Fly   408 EMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVY 472

Mouse   266 AGLDTKIMKNCGKIHLKRTKLDLMMNKLVALIFLSLVIASLLLTVGFTFMVKQFKAKHY---YMS 327
            ||.:||.|.|......||::::..||..|....:.|:|..::..:|....:..|  .|:   |:.
  Fly   473 AGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSF--THFPVPYLP 535

Mouse   328 PTHGRSDAMESFFIFWGFLILLSVMVPMAMFIIAEFIYLGNSIFINWDLNMYYEPLDMPAKARST 392
            |....:: |||.:|||.::::|.||:|:::::..|...:.....|:.:::::....:...:.|:.
  Fly   536 PNKLTAN-MESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAM 599

Mouse   393 SLNDQLGQVQYIFSDKTGTLTQNIMTFKKCCINGCIYDSDDEHGTLRKRNPYAWNPFADGKLQFY 457
            ::.::|||:|:||:|||||||:|.|.|::|.:||    ||..|........|: .|.|.......
  Fly   600 NITEELGQIQHIFTDKTGTLTENKMIFRRCVVNG----SDYNHPPSELEKIYS-KPGAPAPPLIP 659

Mouse   458 NKELES----LVQGR----QDRAVQEFWRLLAICHTVMV-------------------------- 488
            |..|.|    |.||.    ..:.:|||..:||||:||:|
  Fly   660 NDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPAN 724

Mouse   489 ----------------------------------------------------------------- 488

  Fly   725 LKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQ 789

Mouse   489 ----------------------------------------------------------------- 488

  Fly   790 SHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGK 854

Mouse   489 -------------QEKDNQLLYQAASPDEEALVTAARNFGYVFLSRTQDTITLVEL---GEERVY 537
                         :..|.:.||:|.||||.|||.||.::....|:|:.:.| ||.:   |..|.|
  Fly   855 RMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQI-LVSMPMAGATREY 918

Mouse   538 QVLAMMDFNSVRKRMSVLVRNPEGS--ICLYTKGADTVILERL------RSKGVMEATTEEVLAA 594
            ::|.::.|:|.||.||::||. .||  |.|||||||:.|:..|      ..:|::...|:::|..
  Fly   919 EILKVLPFDSSRKCMSIVVRQ-IGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDR 982

Mouse   595 FAEQTLRTLCLAYKDVEEDAYKEWEPEHQEAALLLQNRAQALHQVYNKMEQNLQLLGATAIEDKL 659
            :|.:.||.|.:|.:.:....|.:|...|||..:.|:||.:.|...:.|:|.||.|||||.|||:|
  Fly   983 YAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRL 1047

Mouse   660 QDGVPETIKCLKKGNIKIWVLTGDKPETAVNIGFACQLLSENMIIL----EDKDINQ-VLERYWE 719
            ||||||||..|....|.:|||||||||||:||.::.:|.::.|.::    ..:|..: .:..|..
  Fly  1048 QDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLT 1112

Mouse   720 DNVHQKAFKMMTHHNMALVINGEFLDQLLLSLRKEPRALVQNAVVDEVAQEPVVSALDFLQKRRI 784
            |..:.|....:.:        |:       ||||:.||||.:.           ..|.|:.
  Fly  1113 DMENDKTTSTLGY--------GQ-------SLRKKQRALVVDG-----------KTLTFIL---- 1147

Mouse   785 SQMWRNAGPSLGTSHSADSKIRESPEVQRERAFVDLASKCQAVICCRVTPKQKALVVALVKKYQQ 849
                                   .|:.:....|:.|:.:|.:|:|||.||.|||.:|.:||:...
  Fly  1148 -----------------------DPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELN 1189

Mouse   850 VVTLAIGDGANDVNMIKTADIGVGLAGQEGMQAVQNSDYVLAQFCYLQRLLLVHGRWSYMRVCKF 914
            :.|||||||||||:||:.||:|||::||||||||..:|:.|.:|.||:||||.||.|.|.|:.:.
  Fly  1190 LRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRM 1254

Mouse   915 LRYFFYKTVASMMAQIWFSLVNGFSAQPLYEGWFLALFNLLYSTLPVLYIGLFEQDVTAEKSLKM 979
            :.|||||..|.:....|:.|..|||.|.:.:..:|.|:||::::||.|.||::::.|..:..||.
  Fly  1255 ILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKN 1319

Mouse   980 PELYMAGQKGELFNYSIFMQAITHGTITSMINFFVTVMVSSDMSKAGSSHDYQSLGVLVAISSLL 1044
            |.||..|:.|..:....|...:......|::.|||.:     .:.|.|.......|..:..|.|.
  Fly  1320 PYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVAL-----CAYAESDVGIWEFGTTITASCLF 1379

Mouse  1045 SVTLEVMLVVKYWTLLFVGAVVLSLSSYVLMTSLTQSLWMYRISPKTFPFLFADYNVLF----EP 1105
            :..:...:.::.||:|.|.::||||.|:.|...:..|:.|.....:      :.|.|:|    ..
  Fly  1380 ANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVR------SSYWVIFVCFASA 1438

Mouse  1106 CSLLLIVLNVALNVLPMLALRTIH---------RTVL---KQRPKGE 1140
            ...|:|:|:..:.|||.|.|.|:.         :.:|   ::|.:||
  Fly  1439 VHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQSKRERSRGE 1485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atp8b3	NP_080370.2	PhoLip_ATPase_N	20..96	CDD:292826	28/75 (37%)
		ATPase-Plipid	45..1131	CDD:273734	392/1297 (30%)
		Cation_ATPase	483..580	CDD:289987	46/276 (17%)
		COG4087	<839..890	CDD:226572	30/50 (60%)
		PhoLip_ATPase_C	883..1131	CDD:292829	78/260 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1192..1215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1236..1280
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1314..1335
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	26/49 (53%)
		ATPase-Plipid	250..1473	CDD:273734	392/1297 (30%)
		E1-E2_ATPase	302..>394	CDD:278548	37/91 (41%)
		Cation_ATPase	<880..965	CDD:289987	38/86 (44%)
		HAD_like	<1177..1240	CDD:304363	37/62 (60%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	78/255 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830