Protein Alignment SOS2 and PDZ-GEF

DIOPT Version :10

• Sequence 1: XP_047287669.1
• Gene: SOS2 / 6655
• HGNCID: 11188
• Length: 1397
• Species: Homo sapiens
• Sequence 2: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Alignment Length: 1748
• Identity: 320/1748 - (18%)
• Similarity: 541/1748 - (30%)
• Gaps: 656/1748 - (37%)

Human    48 CNLHLSGSSDSPASASRVAGTTGVCHHAQVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPR 112
            ||   .||..|..|::.....|...::|...|.....||...||:...:|
  Fly    38 CN---RGSHSSDTSSAYSGSDTMASNYASSLEAEEIDLSGLVESVVDSDE--------------- 84

Human   113 TVQDVEERVQKTFPHPIDKWAIADA-QSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLY 176
              :|:.|        .:|...:.|| :..:||    :|.....:.:...|:...|.|...:::|.
  Fly    85 --EDLAE--------SMDSLTVRDAVRDCLEK----DPAERSEEDVEVLLEFTQGLKAFTNITLA 135

Human   177 I-VAVLEYISADILKLAGNYVFN-----------------IRHYEISQQDIKV------------ 211
            : .|:...:...::..||..|.:                 |.|...|::::::
  Fly   136 VRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEIEHANGSREELQMGDSFGILPTMDK 200

Human   212 --------SMCADKPLV----TTFYSASMSLFQIPHVLMD--MFDQDDIGLVSLCEDEPS----- 257
                    :.|.|...|    |.:|       :|.|...:  ...:|:.|.|.:..:..|
  Fly   201 LYHRGVMRTKCDDCQFVCITQTDYY-------RIQHQGEENTRRHEDENGFVVMVTELRSIGGAG 258

Human   258 ------------SSGELNY---YDLVRTEIAEER---QYLRELNMIIKVFREAFLSDRKLFKPSD 304
                        :|..||.   :.::|.  ..||   |.:.|.:|....:.|.||...::|
  Fly   259 TDSAGSGGSATGASASLNMKRGHVVIRG--TPERLLQQLVEENSMTDPTYVEDFLLTHRIF---- 317

Human   305 IEKIFSNISDIHELTVKLLGLIE-------DTVEMTDESSPHPL--AGSCFEDLAEEQAFDPYET 360
                   |.:..|:|.|||...:       .|.|:.|..:...|  ..:.|.|...:     ||.
  Fly   318 -------IQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEAD-----YEM 370

Human   361 LSQDILSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLK- 424
            :       ||.|.|..|:.|.                                    :||.||:
  Fly   371 M-------EFLEVFEALLERK------------------------------------KLLSQLRL 392

Human   425 ---ACSEEQEDREC----------LNQAITALMNLQG-------SMDRIY--------KQYSPRR 461
               ||:.:...|.|          ||..|.....|:|       :...||        |......
  Fly   393 LHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGL 457

Human   462 RPGDPVCPFYSHQLRSK---HLAIKKMNEI-----------QKNIDGWEGKDIGQ---------- 502
            :.||.:     |::..:   |:..|:..||           :.|:.|:  |:|.|
  Fly   458 KRGDQI-----HEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGF--KEIMQALEHGGGTAG 515

Human   503 --------------------CCNEFI-MEG-------PLTRIGAKHERHIFLFDGL-MISCKPNH 538
                                |.|:.. :.|       .|:.:.|.:..|:.....: |:..:|:.
  Fly   516 SGSISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDC 580

Human   539 GQTRLPGYSSAEYRLKEKFVMRKIQI--------------CDKEDTCEHKHAF-ELVSKDENSII 588
            ...:.|..|.:. .:...|:.:.:|.              .|::||   |..| .|..|......
  Fly   581 APPQTPPVSGSG-NMASNFMQQLLQSVNNSSAKKSGGNSNSDQQDT---KGGFMTLAPKRRLQKA 641

Human   589 FAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFED 653
            .|..:...|.|         :.|:|:...|::|    |:...:|            |..:.....
  Fly   642 LAKMNLLNKQN---------HGSSLNDSSDTLL----NDPKSKL------------SAVSSCSSS 681

Human   654 NLQSRSGIPIIKGGTVVK--------------------------LIERLTYHMYAD--------- 683
            ...|.:|..:..||.:.:                          .:..|..|::..
  Fly   682 TQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTN 746

Human   684 -------PNFVRTFLTTYRS--FCK---------PQELLSLLIERFEIPEP-------EPTDADK 723
                   |::....|..|::  .||         ..|::.|.::.|.|.:|       |.:..|.
  Fly   747 STQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDG 811

Human   724 LAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKA 788
            ..:::...|          :.:|.:..||....|::           |:|.:..|..:..
  Fly   812 GMVKQRRLP----------DQLQNLAERISFAARYY-----------LKLNDSTEPLVPD----- 850

Human   789 MKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTL 853
                 |...:::|..          |:.|                      :.|:..|:|.||||
  Fly   851 -----ELALELVRES----------NVHF----------------------LHLNAYELAIQLTL 878

Human   854 LESDLYRKVQPSELVGSVWTKEDKEINS----PNLLKMIRHTTNLTLWFEKCIVEAENFEERVAV 914
            .:...:|:::.:|.|..::     |:.|    |.|.|..........|....|....|...|:.:
  Fly   879 QDFANFRQIESTEYVDELF-----ELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKI 938

Human   915 LSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQD--HFKK 977
            :.:.|:|.:..::..|||.:..|||.:...:|.||..|:|.|..:.:::.::..:|...  :..|
  Fly   939 VKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSK 1003

Human   978 Y--LVKLKSI-NPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQN 1039
            |  ||..:.: ..|.:||:.|...::.....||:    .:...||||.|.|.:|:....:....:
  Fly  1004 YRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGND----TRVDGLINFEKLRMLAKEVRLLTHMCS 1064

Human  1040 QPYCL-------------------------------------------------RIEPDMRRFFE 1055
            .||.|                                                 ...|:.::.||
  Fly  1065 SPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFE 1129

Human  1056 N----------LNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTF---------SLKSP 1101
            .          ||.:...|::   |.|...|||.||.:         .||:         |.:|.
  Fly  1130 EAQMVRRVKAYLNSLKILSDE---DLLHKFSLECEPAH---------GSTYSGSISHGNTSHRSG 1182

Human  1102 GIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNT--------PSTPP 1158
            |....:|..|.:||...|..:.|....         :..:.|..|:.::||:        ||:|.
  Fly  1183 GGGSISGGAGGSSGGGGGGSSSLNAGD---------QLSIYSHTSSSSAPNSSLSLRKRHPSSPT 1238

Human  1159 VSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIP----------PP 1213
            :|.:|..|...|........:...|........|...|...|......:|.:|          ||
  Fly  1239 LSTTSSTSSTSDHQRRQMHNNGPKFGTASPQAVKKMLSLSESSKIRPHQPFVPRHGSTMAGVIPP 1303

Human  1214 LPPRKKFDHDASNSKGNMKSDDDPPAIPPRQ---PPPPKVKPRVP-----VPTGAFDGPLHSPPP 1270
            |.........::.|.|.:.:.....|:...|   .|.|....|:.     :|:.|.....||..|
  Fly  1304 LHHMHAAHGFSTPSPGGVVTSPATSAVANVQCTPSPSPCSHRRLASGGNIIPSRAIHERSHSDTP 1368

Human  1271 PPPRDPLPD-----------TPPPVPLR-----------------PPEHFINCPFNLQ------- 1300
            .|| .|||.           |...:|||                 ..:|     ::||
  Fly  1369 APP-PPLPSVDLSLESSSVTTFRDLPLRKSVTSGSISSCDSGYVHQQQH-----YHLQYQQQQQQ 1427

Human  1301 ------PPPLGHLHRDSDWLRDISTCP-----NSP----STPPSTPS--PRVPRRCYVLSS---- 1344
                  |.|..:...|...|:.||...     |||    :||||||:  |..|.....||:
  Fly  1428 NSSQHEPSPPVYTAADCRLLQQISNNAVTRNLNSPCQSTNTPPSTPTPPPNQPTATIQLSAPPTA 1492

Human  1345 ---------------SQNNLAHPPAPP----VPPRQN---------SSPHLPKLPPKT 1374
                           .|.:||.||.||    |||..:         .|.||..:..||
  Fly  1493 AAYMHARSQHQQLQQQQQSLAMPPPPPPPYNVPPLGSIYSHHQGTAGSRHLNHMHGKT 1550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOS2	XP_047287669.1	HFD_SOS1_rpt1	18..142	CDD:467039	19/94 (20%)
		HFD_SOS1_rpt2	151..219	CDD:467040	13/105 (12%)
		RhoGEF	264..451	CDD:238091	43/222 (19%)
		PH_SOS	502..608	CDD:269963	23/159 (14%)
		RasGEFN	660..804	CDD:214571	27/203 (13%)
		RasGEF	839..1078	CDD:238087	63/306 (21%)
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999	15/115 (13%)
		RasGEFN	279..400	CDD:214571	36/181 (20%)
		PDZ_RapGEF2_RapGEF6-like	404..496	CDD:467237	17/96 (18%)
		RA_PDZ-GEF1	759..841	CDD:340483	17/102 (17%)
		RasGEF	871..1050	CDD:459872	48/187 (26%)