DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC16A2 and CG13907

DIOPT Version :9

Sequence 1:	NP_006508.2	Gene:	SLC16A2 / 6567	HGNCID:	10923	Length:	539	Species:	Homo sapiens
Sequence 2:	NP_001286894.1	Gene:	CG13907 / 38104	FlyBaseID:	FBgn0035173	Length:	816	Species:	Drosophila melanogaster

Alignment Length:	747	Identity:	138/747 - (18%)
Similarity:	232/747 - (31%)	Gaps:	318/747 - (42%)

- Green bases have known domain annotations that are detailed below.

Human    94 PPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCS 158
            ||:||:|||:.||:..||..:.||..:.||    .|||......:.:...||||:|..|:.....
  Fly    71 PPDGGYGWVICFASFMCNMIVDGIAYTFGI----FLEEFVAYFHEGKGTVAWVGSLLSGVYLSAG 131

Human   159 PIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHY 223
            ||||...::.|||....||:.:|.|....|:|::::|:...|||.:.|.|....:.|::|.:|:|
  Fly   132 PIVSALANKYGCRAVCIAGSIIACIAFVLSTFSTNVSMLMATYGFMGGFGFGMIYLPAVVAVGYY 196

Human   224 FQRRLGLANGVVSAGSSIFSMSF----PFLIRMLGDKIKLAQTFQ--VLSTFMFVLMLLSLTY-- 280
            |:.:..||.|:...||...:.:|    .:|:...|.|..|. .|.  :|:..:|..|:..|||
  Fly   197 FETKRSLATGIAVCGSGFGTFAFAPLATYLLEEYGWKNALL-IFAGLILNCAIFGAMMRPLTYPK 260

Human   281 ----RPL---------------------------------------------------------- 283
                :||
  Fly   261 KKKQKPLMQRMYEEKQLQLERGSFAGSHFMVQLPDGTIERKLKMPLNADPGVHSSLNLELLAQQA 325

Human   284 ----------LPS---------------------------------------------------- 286
                      ||:
  Fly   326 GGGGLHPVSTLPTITESKVVDVHRQNGAQSPPNGDSNGQLSARSAAGAVGRRPHRNSESENSPYH 390

Human   287 SQDT-----------------------------------------PSKRGVR------------- 297
            |||.                                         ||...:|
  Fly   391 SQDAMTRNASQPAFLAGDHQSLPKNGSVPAFNTRVRKTSASERFQPSLAAIRATSRGDLEAGAGG 455

Human   298 -------TLHQRF---------------------------------------------------- 303
                   :|.||.
  Fly   456 DFASSKLSLSQRQGGSQTGSSGRMVRPMSRKDIFYSGSVTNLPQYQSQKSLANYRNSVLSLTKYE 520

Human   304 -----------LAQLRKY-----------------------FNMRVFRQRTYRIWA----FGIAA 330
                       ||:..|:                       .::.:.:...:.:..    ||:|
  Fly   521 KSMQSVAKLDPLAEAEKHREEYDLCPCLGIPDSVKSVVNTMLDVSLLKDPVFMLIGVSNIFGMA- 584

Human   331 AALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFL 395
               |.:||:|:|:...:|......:..:||..||.|:.:||:..|.::| :|.:..:.|.....|
  Fly   585 ---GLYVPFVYLVDAAKEHDIPKNDAAMLLSIIGITNTVGRVFCGWVAD-LPQVNSLLLNNCCLL 645

Human   396 LLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMI 460
            :..:...:.|||..:...|.:.:|.||....:|::.:.|..:|:|..:.:.|.|.|:.......:
  Fly   646 VSTIAVTLTPLCYSYAAYITMSIFFGLAISGYISLTSIILVDLLGLDKLTNAFGLLILFRGFAAL 710

Human   461 AGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQ--------------RMFKKEQRD 511
            .|.|:||.:.:....|.:.||.||....|..:..|..|.:.:              ....:||.:
  Fly   711 IGTPLAGAIYDMTHTYDLPFYMAGALFGISTITSFLAPCLKRCSPSEETPVHVETLTPIDEEQGE 775

Human   512 SSKDKMLAPDPDPNGELLP------GSPNPEE 537
            .::|     |.|....::|      .||..||
  Fly   776 DAED-----DEDQPITIVPKIIKTLASPQQEE 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A2	NP_006508.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92
		2A0113	86..513	CDD:273325	130/715 (18%)
		MFS	101..498	CDD:119392	122/679 (18%)
		DUF1564	<286..>334	CDD:284922	15/250 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..539		10/36 (28%)
CG13907	NP_001286894.1	MFS	78..>258	CDD:119392	58/184 (32%)
CG13907	NP_001286894.1	MFS	<570..748	CDD:119392	46/182 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145580
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750