Protein Alignment SLC6A7 and CG8850

DIOPT Version :10

• Sequence 1: XP_016865256.1
• Gene: SLC6A7 / 6534
• HGNCID: 11054
• Length: 754
• Species: Homo sapiens
• Sequence 2: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 642
• Identity: 224/642 - (34%)
• Similarity: 348/642 - (54%)
• Gaps: 62/642 - (9%)

Human    82 MKKLQGAHLRKPVTPDLLMTP--SDQGD-----VDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLG 139
            |:..||:....|.:.|.:.|.  |.:|:     .:.:.:.:..|..|:..::||.|||...||||
  Fly    14 MQGAQGSREGHPGSNDGISTVIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLG 78

Human   140 NVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAML 204
            ||||||:.|..|||||||:||.::|.:.|.|:::||:.:|||||.|.:..:.::|:.:|.....:
  Fly    79 NVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQV 143

Human   205 LIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVS 269
            ....|...||..|:|..:.||.||.:..|||.:|...|. :.|    |:.....|...::...||
  Fly   144 YSTALATTYYACIMALTIRYLVASFSEVLPWTYCLVEWG-KSC----VATGATAANDSSIVQGVS 203

Human   270 PSEEYWSQTHTEAEEEGRRGRVVSNSYPQVIFLPQPPKAEEGVSRYVLHIQGSQGIGSPGEIRWN 334
            .:|.:::||                      .|.:|...::            .|:|:|.   |:
  Fly   204 SAELFFTQT----------------------VLREPESLDD------------NGLGTPS---WD 231

Human   335 LCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHH 399
            |.||||..|||:...:.||::||||..||.|.|||:|:::||:|.|||||||:||.::|.||:..
  Fly   232 LVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQ 296

Human   400 LLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLG 464
            ||:..||..|..|:|:||.:.||.|:.:||:|.|::|:::|..|:|..:::||||||..||.:||
  Fly   297 LLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILG 361

Human   465 YMSQELGV-PVDQVAKAGPGLAFVVYPQAMTMLPLSP-FWSFLFFFMLLTLGLDSQFAFLETIVT 527
            .::.|... .:.||.|.|.||||:.||:|:......| .::.|||||||.||:.|.......:|.
  Fly   362 NLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVN 426

Human   528 AVTDEF---PYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCL 589
            .|.|.|   |::|....|...|.:|      ||:..|.||.:.|.|:|.|..:|..:|:.|...|
  Fly   427 VVKDRFTHLPHWLLAVSASIIGFLC------GLVYMTPGGQFVLNLVDFYGCTFIALVLAIAELL 485

Human   590 AVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAE 654
            ||..:||::|.|.||..||..|...|:|.||..::|..:..::||.:..|:|..|...::||...
  Fly   486 AVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYY 550

Human   655 LLGILMGLLSCLMIPAGMLVAVLREEGSLW-ERLQQASRPAMDWGPSLEENRTGMYV 710
            :.|.::..|..|.:|...||.:.::.|..: .:...|.:|..:||| |:..:...|:
  Fly   551 MAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQPTANWGP-LQTQKFEAYI 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A7	XP_016865256.1	SLC6sbd_PROT	118..699	CDD:271390	212/586 (36%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	196/521 (38%)