Protein Alignment SLC2A3 and pippin

DIOPT Version :10

• Sequence 1: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Sequence 2: NP_726368.2
• Gene: pippin / 37770
• FlyBaseID: FBgn0034909
• Length: 533
• Species: Drosophila melanogaster
• Alignment Length: 456
• Identity: 125/456 - (27%)
• Similarity: 200/456 - (43%)
• Gaps: 50/456 - (10%)

Human    60 TSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGR 124
            |..|..||  .|:....||...|...:..|||.::::..:..:.|...:.   :|||::::|..|
  Fly   100 TGSWIASV--HSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLA---IAKSIKVVIFAR 159

Human   125 LVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLG 189
            .:.|...|:..|...:||.|.:...||........:....|||:.      :.|||...|..:..
  Fly   160 FLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMV------YSLGSMMYWRSVAW 218

Human   190 FTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQ 254
            ...:..:|...::.|.||:|.:||.| ..|:.|.|.|..|.|::..:|  :|:.|...|:::|:.
  Fly   219 CANVLPLLSMVSISFIPETPAWLLRN-GHEKRALQALSFLRGSEISAQ--KELNDMKQRLAKERV 280

Human   255 VTVL--ELFRVSSYR---QPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQ-EPIYATIGAGV 313
            .|..  .:|::...|   :|::|.||..|.|..||...|.:|:..:..:.|.: :...|.|...|
  Fly   281 TTKTNENIFQLCCQRVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSKQAAIATAV 345

Human   314 VNTI----FTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKD----NYNGMSFVCIGAI 370
            |..|    |.||.:| |.|  ||.:.:.|:|...||..|........|    :|:  .||..|.:
  Fly   346 VRVICCMVFCVVLIF-VRR--RRIMIVSGIGSGLFCLVLSVYQYARFDQPKMSYD--VFVGAGCL 405

Human   371 LVFVAF---FEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAY-V 431
            |.::.|   ..:.||    .::.|||....|.........|...:.|:....||:....|... |
  Fly   406 LGYIIFNTALMVMPG----IMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGV 466

Human   432 FIIF--TGFLITFLAFTFFKVPETRGRTFEDITRAFEGQA---HGADRSGKDGVMEMNSIEPAKE 491
            |::|  :.||:|  ||.....|||:||:.|.|...|.|..   ...||..|  .:.:..:||.|:
  Fly   467 FLVFGVSSFLLT--AFMCLFQPETKGRSLEHIEDYFNGDNWLWFRRDRGYK--TVNLQPLEPLKD 527

Human   492 T 492
            |
  Fly   528 T 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	112/415 (27%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)
pippin	NP_726368.2	MFS_GLUT6_8_Class3_like	59..495	CDD:340916	114/419 (27%)