Protein Alignment SLC2A3 and CG6484

DIOPT Version :9

• Sequence 1: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Sequence 2: NP_611234.1
• Gene: CG6484 / 36994
• FlyBaseID: FBgn0034247
• Length: 465
• Species: Drosophila melanogaster
• Alignment Length: 482
• Identity: 161/482 - (33%)
• Similarity: 247/482 - (51%)
• Gaps: 44/482 - (9%)

Human     1 MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSL 65
            |....|.|..|..:: |:.|:...|.:.|..:..|.:|      |:..:...|.|    :|.:..
  Fly     1 MSKGSVLPQYIAGLS-ASFGALCMGASIGWSSPVENMI------TVNTEYGFPIS----SSQFGW 54

Human    66 SVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLF 130
            ..::.::|..:....:|..::..|||.:||.:....:.|...|   ..||:|.||..||.::|:.
  Fly    55 VSSLLTLGATVICIPIGFAIDWIGRRPTMLALIPPYMVGWVLM---LFAKNVTMLYFGRFILGMC 116

Human   131 CGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLL---LGFTI 192
            .|......|||..||:.|||||..|:..||.||.|:|...:.| .|:       |||   :...|
  Fly   117 GGAFCVTAPMYCTEITATALRGTIGSFFQLLIVSGVLYGYLVG-AFL-------PLLTINILCAI 173

Human   193 LPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQ-DVSQDIQEMKDESARMSQEKQVT 256
            ||.|...... |.||||.:|.:..:.::.|| .||.|.|.. |:..:::|:.:||.:.....||.
  Fly   174 LPVIFAIIHF-FMPESPVYLAMKGRNDDAAK-ALQWLRGKDADIDDELKEILEESQKQIDMPQVN 236

Human   257 VLELFRVSSYRQPII-----ISIVLQLSQQLSGINAVFYYSTGIFKDAGVQ-EPIYATIGAGVVN 315
            :|     ||.|:||:     |:::||:.||.:|||||.:||..||:|.|.. ....||:..||..
  Fly   237 IL-----SSLRRPIVLKGLGIAVLLQVFQQWTGINAVLFYSASIFEDTGSDISGSDATLIIGVTQ 296

Human   316 TIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDN----YNGMSFVCIGAILVFVAF 376
            ...|:|::.::::||||.|.:|....||..:.||.|...||:|    .:...::.|.:|.:|:.|
  Fly   297 VTSTLVAVAIIDKAGRRILLLISGVLMAVSTALMGVYFQLKENDPASMDNFGWLPISSICIFIIF 361

Human   377 FEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLG-AYVFIIFTGFLI 440
            |.||.||:||.::|||||:..:..|.::||.|||.|.|:|.||||.....:| ...|.|||...:
  Fly   362 FSIGFGPVPWLVMAELFSEDVKSVAGSIAGTSNWLSAFVVTLLFPILKSSIGPGPTFWIFTAIAV 426

Human   441 TFLAFTFFKVPETRGRTFEDITRAFEG 467
            ....::.|.||||:|:|..:|.....|
  Fly   427 IAFFYSLFFVPETKGKTIIEIQDLLSG 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	153/458 (33%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		1/1 (100%)
		Monosaccharide binding. /evidence=ECO:0000269|PubMed:26176916	280..286		3/5 (60%)
CG6484	NP_611234.1	Sugar_tr	14..451	CDD:278511	156/465 (34%)
		MFS	14..436	CDD:119392	149/450 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143894
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840