Protein Alignment SLC2A3 and Tret1-2

DIOPT Version :9

• Sequence 1: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Sequence 2: NP_610694.1
• Gene: Tret1-2 / 36249
• FlyBaseID: FBgn0033644
• Length: 488
• Species: Drosophila melanogaster
• Alignment Length: 499
• Identity: 144/499 - (28%)
• Similarity: 233/499 - (46%)
• Gaps: 89/499 - (17%)

Human     5 KVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAI 69
            :|..||..::....:|......:..:::..::.|..|  :...|.|:           |
  Fly    28 QVLAALSVSLCSLVVGFVSAYTSPALVSMTDRTITSF--EVTKDAGS-----------W------ 73

Human    70 FSVGGMI------GSFSVGLFVNRFGRRNSML------IVNLLAVTGGCFMGLCKVAKSVEMLIL 122
              |||::      |..:.|..:...|||:::|      ||:.|.:.       |.|  :|.|::.
  Fly    74 --VGGIMPLAALAGGITGGPLIEYLGRRSTILATAVPFIVSSLLIA-------CAV--NVIMILC 127

Human   123 GRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTL-NQLGIVVGILVAQIFGLEFILGSEELWPL 186
            ||.:.|...|:.:..:|:|:||.....:||..|.| ..|| .:||||.      ::.||...|.:
  Fly   128 GRFLTGFCVGIASLSLPVYLGETLQPEVRGTLGLLPTALG-NIGILVC------YVAGSFMNWSM 185

Human   187 LLGFTILPAILQSAALP--------FCPESPRFLLINRKEEENAKQILQRLWGTQ-DVSQDIQE- 241
            |       |.| .||||        ..||:||: .:||.:||.|::.|:.|.|.: ||..:::|
  Fly   186 L-------AFL-GAALPVPFLILMIIIPETPRW-FVNRGQEERARKALKWLRGKEADVEPELKEL 241

Human   242 MKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAG-VQEPI 305
            |:.::....|..|.|.||||:.::.: |:.||:.|...||.||||||.:|:..|||||| ..:..
  Fly   242 MQSQADADRQATQNTCLELFKRNNLK-PLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDSN 305

Human   306 YATIGAGVVNTIFTVVSLFLVERAGRRTLHMIG----------LGGMAFCSTLMTVSLLLKDNYN 360
            .:||..||||...|.:.:.|::|.||:.|..:.          |||..:|..       ...:.:
  Fly   306 LSTIIVGVVNFFATFMGIILIDRLGRKILLYVSDIAMIVTLSILGGFFYCKA-------HGPDVS 363

Human   361 GMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAH 425
            .:.::.:...::::..|.:|.|||||.::.|:.....|..|.:|....||...|:|...|.....
  Fly   364 HLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTV 428

Human   426 YLGAY-VFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQ 468
            .:||: .|.:|....|..|.|....||||||::.|:|.|...|:
  Fly   429 AMGAHGAFWLFGAICIVGLFFVIIFVPETRGKSLEEIERKMMGR 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	136/478 (28%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)
		Monosaccharide binding. /evidence=ECO:0000269|PubMed:26176916	280..286		4/5 (80%)
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	141/489 (29%)
		MFS	33..454	CDD:119392	132/474 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143965
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740