Protein Alignment SLC2A3 and sut1

DIOPT Version :10

• Sequence 1: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Sequence 2: NP_523658.1
• Gene: sut1 / 35774
• FlyBaseID: FBgn0028563
• Length: 507
• Species: Drosophila melanogaster
• Alignment Length: 460
• Identity: 176/460 - (38%)
• Similarity: 255/460 - (55%)
• Gaps: 21/460 - (4%)

Human    10 LIFAITVATI--GSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSV 72
            |:..:.:||.  |:...||..||||||.|::|.:.|:||.|...:..|...|..|||..|::|.|
  Fly    38 LLLLVALATTFGGAVSTGYCIGVINAPSKLMKVWCNQTLHDTYGSNLSAGGLDLLWSCVVSVFLV 102

Human    73 GGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGF 137
            ||.|||.......|:|||:...||...|...|......|:.|.|||||::||.|:||..||.|..
  Fly   103 GGAIGSLGGAGAANKFGRKACFLICGALFTVGAVLFFFCRAASSVEMLVIGRFVVGLASGLVTAT 167

Human   138 VPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLG---FTILPAILQS 199
            :|||:.|::|.||||..|....:|:..|::|.|:..|..:.|:|:||...|.   |.||...|.|
  Fly   168 LPMYLSEVAPMALRGTLGVFIAVGVTGGVVVGQVCSLANVFGTEDLWHYALTAYMFLILVCYLPS 232

Human   200 AALPFCPESPRFLLINRKEEENAKQILQRLWG---TQDVSQDIQEMKDESARMSQEKQVTVLELF 261
            ...   ||||:||.|.:.....||:.||||.|   .:.::|::.||:.||....|..  :..::.
  Fly   233 YLF---PESPKFLYIVKGNRAAAKRELQRLRGKDAEELIAQEMAEMEAESNAKVQTS--SFCDVL 292

Human   262 RVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQ--EPIYATIGAGVVNTIFTVVSLF 324
            |......|:||.......||||||||:||||..||:.||:.  :..:|.:|||.:|...:::..:
  Fly   293 RDPRLTLPLIIVCCFHGGQQLSGINAIFYYSVSIFEKAGLSTVDAQWANLGAGCLNLAVSLLGPW 357

Human   325 LVERAGRRTLHMIGLGGMAFCST-LMTVSLLL--KDNYNGMSFVCIGAILVFVAFFEIGPGPIPW 386
            |:.:..||||.|.   ..|.||. |.|::.:|  .|..:..:..||..|:.::.|::.|.||||:
  Fly   358 LMAKCNRRTLMMF---SCALCSVFLFTIAFVLFYIDQVSWFAIACIVCIMGYIFFYQFGLGPIPY 419

Human   387 FIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVP 451
            ||.||||...||..||::...::||.||::|:.||...:..||:||:.|:...:.....|.|.:|
  Fly   420 FIGAELFEVAPRSVAMSMGSLASWTCNFIIGISFPLLQNAWGAFVFLPFSITCVLLFLLTKFYLP 484

Human   452 ETRGR 456
            |||||
  Fly   485 ETRGR 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	173/456 (38%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)
sut1	NP_523658.1	MFS_GLUT_Class1_2_like	48..489	CDD:340915	171/448 (38%)