Protein Alignment WNK1 and Madm

DIOPT Version :10

• Sequence 1: XP_011519299.1
• Gene: WNK1 / 65125
• HGNCID: 14540
• Length: 2795
• Species: Homo sapiens
• Sequence 2: NP_649581.1
• Gene: Madm / 40710
• FlyBaseID: FBgn0027497
• Length: 637
• Species: Drosophila melanogaster
• Alignment Length: 699
• Identity: 170/699 - (24%)
• Similarity: 267/699 - (38%)
• Gaps: 220/699 - (31%)

Human   131 SQVAQQP----PAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPP----ARSGSGG 187
            |.||.:|    |:.|       |||..::.|::|    |.||     |.::|||    |.:...|
  Fly    13 STVADEPIQHHPSLA-------AGPVSASCPAAT----PPSQ-----STQQPPPHIVSASTADAG 61

Human   188 GSA----------------KEPQEERSQQQDDIEELETKAVGMSNDGRFLKFDIEIGR---GSFK 233
            .||                ..|:|.....:|:.|.||.     |..||:||...|:.:   ....
  Fly    62 SSAAVGVGVVAGSEGVNLDSSPRESGDDSEDESEILEE-----SPCGRWLKRREEVDQRDVPGID 121

Human   234 TVYKGLDTETTVEVAWCELQDRKL--TKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKK- 295
            .|:..:|||..|||.|.|:|...|  .||:.::.::..:.|..|.|.|||:|:..|..|.:.::
  Fly   122 CVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERP 186

Human   296 CIVLVTELMTSGTLKTYLKR----FKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIF 356
            .:|.:||.|:||:||.:|||    .|.:.::..|.||.|||..|.:||:.:|||||.:|.||:||
  Fly   187 RVVFITEYMSSGSLKQFLKRTKRNAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIF 251

Human   357 ITGPTGSVKIGDLGLATLKRASFAKSVI--------------------GTPEFMAPEM-YEEKYD 400
            |. ..|.||||              ||:                    |...|.|||. ..::..
  Fly   252 IQ-HNGLVKIG--------------SVVPDAVHYSVRRGRERERERERGAHYFQAPEYGAADQLT 301

Human   401 ESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPE-------------- 451
            .::|:||||||.||||..|                   ::|::.:..||.|
  Fly   302 AALDIYAFGMCALEMAALE-------------------IQPSNSESTAINEETIQRTIFSLENDL 347

Human   452 VKEIIEGCIRQNKDERYSIKDLLNHAFFQE-----------------------ETG--------- 484
            .:::|..|:.....:|.|..|||.|....|                       ||.
  Fly   348 QRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAHCLVFSPANRTMFSETAFDGLMQRYY 412

Human   485 ------VRVELAEEDDGE------KIAIKLWLRIEDIK-------KLKGKYKDNEAIEFSFDLER 530
                  .::.||...:.:      ..|.||...:||:|       ...||...|.....:.....
  Fly   413 QPDVVMAQLRLAGGQERQYRLADVSGADKLEKFVEDVKYGVYPLITYSGKKPPNFRSRAASPERA 477

Human   531 DVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQ-----LVREEQEKKKQEESSLK 590
            |..:....|.|:          |.::.|.:.:..:|.|.:...     |:|.:.:..:|    |.
  Fly   478 DSVKSATPEPVD----------TESRRIVNMMCSVKIKEDSNDITMTILLRMDDKMNRQ----LT 528

Human   591 QQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVE----PEEPEADQHQQLQYQQPSISVLS 651
            .||.::.                     |:|.:::::.    ....:.|:.|.|..:.....|:|
  Fly   529 CQVNEND---------------------TAADLTSELVRLGFVHLDDQDKIQVLLEETLKAGVMS 572

Human   652 DGTVDSGQGSSVFTESRVSS-QQTVSYGSQHEQAHSTGTVPGHIPSTVQ 699
            ||......|:.|.|.:.::: :|.....|....|...||...::|...|
  Fly   573 DGAGAESSGAGVTTTATMAALEQLERNWSISSDADKQGTAVMYVPQEQQ 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNK1	XP_011519299.1	STKc_WNK1	195..483	CDD:270932	102/355 (29%)
		OSR1_C	500..563	CDD:463491	13/69 (19%)
		PHA03247	<1178..1507	CDD:223021
		PHA03247	<1986..2280	CDD:223021
Madm	NP_649581.1	PK_NRBP1_like	114..376	CDD:270886	90/295 (31%)