Protein Alignment PINK1 and MEK1

DIOPT Version :8

• Sequence 1: NP_115785.1
• Gene: PINK1 / 65018
• HGNCID: 14581
• Length: 581
• Species: Homo sapiens
• Sequence 2: NP_014996.3
• Gene: MEK1 / 854533
• SGDID: S000005878
• Length: 497
• Species: Saccharomyces cerevisiae
• Alignment Length: 291
• Identity: 75/292 (26%)
• Similarity: 120/292 (41%)
• Gaps: 83/292 (28%)

Human   271 HPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYPCTLRQYL----CV 331
            |||||:|...|...    ...|..:.|::|          |..||           .||    |:
Yeast   220 HPNIIKVYHTFCDR----NNHLYIFQDLIP----------GGDLF-----------SYLAKGDCL 259

Human   332 NTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFGCCLADESIGL 396
            .:.|...:.:::.|:|:.:::|..|.|.|||||.||||: ..|:.|..:|:||||..
Yeast   260 TSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILL-CTPEPCTRIVLADFGIA-------- 315

Human   397 QLPFSSWYVDRGGNGCLM----------APEVSTARPGPRAVIDYSKA------------DAWAV 439
                    .|...|...|          ||||. .|...:|...:|:|            |.|::
Yeast   316 --------KDLNSNKERMHTVVGTPEYCAPEVG-FRANRKAYQSFSRAATLEQRGYDSKCDLWSL 371

Human   440 GAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALP------ESVPPDVRQLVRALLQREASKRP 498
            |.|.:.:...::||||.|.   |....|.|::..|.      :.|..:.:..|:.|||.:..||.
Yeast   372 GVITHIMLTGISPFYGDGS---ERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRL 433

Human   499 SARVAANVLHLSLW-GEHILALKNLKLDKMV 528
            :::  ..:.|  :| .:|:..|:.|...|::
Yeast   434 NSK--QGLKH--IWIAKHLSQLERLYYKKIL 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PINK1	NP_115785.1	STKc_PINK1	162..512	CDD:270920	70/273 (26%)
MEK1	NP_014996.3	FHA	28..122	CDD:238017
		STKc_CAMK	160..443	CDD:270687	70/273 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950		0	Normalized mean entropy	S4469
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950