DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PINK1 and MEK1

DIOPT Version :9

Sequence 1:	NP_115785.1	Gene:	PINK1 / 65018	HGNCID:	14581	Length:	581	Species:	Homo sapiens
Sequence 2:	NP_014996.3	Gene:	MEK1 / 854533	SGDID:	S000005878	Length:	497	Species:	Saccharomyces cerevisiae

Alignment Length:	291	Identity:	75/291 - (25%)
Similarity:	120/291 - (41%)	Gaps:	83/291 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   271 HPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYPCTLRQYL----CV 331
            |||||:|...|...    ...|..:.|::|          |..||           .||    |:
Yeast   220 HPNIIKVYHTFCDR----NNHLYIFQDLIP----------GGDLF-----------SYLAKGDCL 259

Human   332 NTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFGCCLADESIGL 396
            .:.|...:.:::.|:|:.:::|..|.|.|||||.||||: ..|:.|..:|:||||..
Yeast   260 TSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILL-CTPEPCTRIVLADFGIA-------- 315

Human   397 QLPFSSWYVDRGGNGCLM----------APEVSTARPGPRAVIDYSKA------------DAWAV 439
                    .|...|...|          ||||. .|...:|...:|:|            |.|::
Yeast   316 --------KDLNSNKERMHTVVGTPEYCAPEVG-FRANRKAYQSFSRAATLEQRGYDSKCDLWSL 371

Human   440 GAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALP------ESVPPDVRQLVRALLQREASKRP 498
            |.|.:.:...::||||.|.   |....|.|::..|.      :.|..:.:..|:.|||.:..||.
Yeast   372 GVITHIMLTGISPFYGDGS---ERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRL 433

Human   499 SARVAANVLHLSLW-GEHILALKNLKLDKMV 528
            :::  ..:.|  :| .:|:..|:.|...|::
Yeast   434 NSK--QGLKH--IWIAKHLSQLERLYYKKIL 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PINK1	NP_115785.1	Required for outer membrane localization. /evidence=ECO:0000269\|PubMed:30733118	111..117
		STKc_PINK1	162..512	CDD:270920	70/272 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..208
MEK1	NP_014996.3	FHA	28..122	CDD:238017
MEK1	NP_014996.3	STKc_CAMK	160..443	CDD:270687	70/272 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4469
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860