Protein Alignment PINK1 and pink1

DIOPT Version :8

• Sequence 1: NP_115785.1
• Gene: PINK1 / 65018
• HGNCID: 14581
• Length: 581
• Species: Homo sapiens
• Sequence 2: NP_001008628.1
• Gene: pink1 / 494085
• ZFINID: ZDB-GENE-041212-53
• Length: 574
• Species: Danio rerio
• Alignment Length: 604
• Identity: 320/605 (53%)
• Similarity: 394/605 (65%)
• Gaps: 59/605 (10%)

Human     1 MAVRQALGRGLQLGRALLLRFTGKPGRAYGLGRP-GPAAGCVRGE-----RPGWAAGPGAEPRRV 59
            |:|:..|.|||:|||::.         ..||.:| |..|...|||     ||.....|..
Zfish     1 MSVKHVLSRGLELGRSVF---------QLGLLKPAGRVAAKFRGERLRVSRPTRTVQPQT----- 51

Human    60 GLGLPNRLRFFRQSVAGLAARLQRQFVVRAWGCAGPCGRAVFLAFGLGLGLIEEKQAESRRAVSA 124
              .||.|.||||.||:||||:||.....|..|......||||||||:||||||::|.|.|.:.:.
Zfish    52 --FLPGRYRFFRLSVSGLAAQLQSGAFRRVIGGGSARNRAVFLAFGVGLGLIEQEQEEDRTSAAL 114

Human   125 CQEIQAIFTQKS-KPGPDPLDTRRLQGFRLEEYLIGQSIGKGCSAAVYEATMPTLPQNLEVTKST 188
            ||||||:|.:|. :..|.|..:    |:|||:|:||:.|||||:||||||..|..|. :| :|..
Zfish   115 CQEIQAVFRKKKFQSLPKPFTS----GYRLEDYVIGKQIGKGCNAAVYEAAAPFAPP-VE-SKKC 173

Human   189 GLLPGRGPGTSAPGEGQE--RAPGAPAFPLAIKMMWNISAGSSSEAILNTMSQELVPA------- 244
            .|:...........:.:|  |...:|:||||:||||||.|||||:|||.:||.||||:
Zfish   174 SLVELNQKEAEDDNKKEEPLRLSASPSFPLAMKMMWNIGAGSSSDAILRSMSMELVPSCPQALRK 238

Human   245 --SRVALAGEYGAVTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEG 307
              ..:.|.|.:|||        ||:|:.|||:|.|.||||:.|||||||..:||||||:||:|.|
Zfish   239 EQGELTLNGHFGAV--------PKRLSAHPNVITVYRAFTAEVPLLPGAREEYPDVLPTRLNPHG 295

Human   308 LGHGRTLFLVMKNYPCTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVEL 372
            ||..||||||||||||||||||.|..|....|::|.||||||||||.:|.||||||||||||:|.
Zfish   296 LGSNRTLFLVMKNYPCTLRQYLEVCVPKRTQASLMFLQLLEGVDHLCRQNIAHRDLKSDNILLEF 360

Human   373 DPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVSTARPGPRAVIDYSKADAW 437
            |..|||.|||.|||||||::| ||:||||||:|:||||.||||||||||.|||..||||||||.|
Zfish   361 DNTGCPRLVITDFGCCLAEDS-GLKLPFSSWWVNRGGNSCLMAPEVSTAVPGPGVVIDYSKADVW 424

Human   438 AVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREASKRPSARV 502
            ||||||||:||..||||     .||||||||.||||||.:.|.||:.:|:.||::...|||||||
Zfish   425 AVGAIAYELFGQPNPFY-----TLESRSYQEKQLPALPAAAPDDVQLVVKLLLRKNPHKRPSARV 484

Human   503 AANVLHLSLWGEHIL-ALKNLKLDKMVGWLLQQSAATLLANRLTEKCCVETKMKMLFLANLECET 566
            |||:||:||||..:| .|..:::.:|:.||..|||..||..|..::..||.:::..||||:|.|.
Zfish   485 AANILHISLWGRRVLMGLDKVQMAEMMAWLQCQSAVVLLKGRGRDQSSVEAELQRSFLANIELED 549

Human   567 LCQAALLLC----SWRAAL 581
            |..|...:.    .||:.|
Zfish   550 LRTAVSFMTYERKQWRSLL 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PINK1	NP_115785.1	STKc_PINK1	162..512	CDD:270920	223/361 (62%)
pink1	NP_001008628.1	STKc_PINK1	149..494	CDD:270920	223/361 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG4158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000				H32672
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D137670at7742
OrthoFinder	1	1.000				FOG0007807
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900				OOG5_134199
Panther	1	1.100			LDO	PTHR22972
Phylome	1	0.910		0.667	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
ZFIN	1	1.500
	10	10.290