Protein Alignment PINK1 and pink-1

DIOPT Version :8

• Sequence 1: NP_115785.1
• Gene: PINK1 / 65018
• HGNCID: 14581
• Length: 581
• Species: Homo sapiens
• Sequence 2: NP_495017.1
• Gene: pink-1 / 173918
• WormBaseID: WBGene00017137
• Length: 641
• Species: Caenorhabditis elegans
• Alignment Length: 500
• Identity: 158/500 (32%)
• Similarity: 248/500 (50%)
• Gaps: 72/500 (14%)

Human   117 ESRRAVSACQEIQAIFTQKSKPGPDPLDTRRLQGFRLEEYLIGQSIGKGCSAAVYEATMPTLPQN 181
            |..|.|...:.|:.||....:...|...|....  |::.|..|:.:|:||:||||.|.:..  .:
 Worm   100 ELPRNVDLVERIRQIFGNSLRYNEDLKSTEWPN--RIDSYEFGEFLGQGCNAAVYSARLAN--SD 160

Human   182 LEVTKSTGLLPGRGPGTSAPGE-------GQERAPGAPAFPLAIKMMWNISAGSSSEA-ILNTMS 238
            .|.:.:|....|....|:...|       .|::      ||||||:|:|.......:| :|.:|.
 Worm   161 AESSGNTHYGAGFNEVTNILAEIPPVSKVAQKK------FPLAIKLMFNFEHDRDGDAHLLKSMG 219

Human   239 QELVPASRVA--LAGEYGAVTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVL-P 300
            .||.|....|  |.|:.|  |:|...      |.|||::|:..||..|:.:||.|:..|||.| .
 Worm   220 NELAPYPNAAKLLNGQMG--TFRPLP------AKHPNVVRIQTAFIDSLKVLPDAIERYPDALHT 276

Human   301 SRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKS 365
            :|.:.......:|:::||:.|..||.:|:.....:.....:::.||||...:|.:..:|.||:||
 Worm   277 ARWYESIASEPKTMYVVMRRYRQTLHEYVWTRHRNYWTGRVIIAQLLEACTYLHKHKVAQRDMKS 341

Human   366 DNILVELD-PDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVSTARPGPRAVI 429
            ||||:|.| .|..|.||:|||||.||.::  .|:.:.|..|..|||....|||::||.||....:
 Worm   342 DNILLEYDFDDEIPQLVVADFGCALACDN--WQVDYESDEVSLGGNAKTKAPEIATAVPGKNVKV 404

Human   430 DYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREA 494
            ::..||.||.|.::||:....||||    ..|::.:|||::|||||..|....|.::..||:|:.
 Worm   405 NFEMADTWAAGGLSYEVLTRSNPFY----KLLDTATYQESELPALPSRVNFVARDVIFDLLKRDP 465

Human   495 SKRPSARVAANVLHLSLW--GE----------------------HILALK-NLKLDKMVGWLLQQ 534
            ::|....:|||.|:|||:  ||                      .:|:.| |.:|||::..:..:
 Worm   466 NERVKPNIAANALNLSLFRMGEDVKQMMEKCGISQMTTLLAGSSKVLSQKINSRLDKVMNLITAE 530

Human   535 SAATLLANRLTEKCCVETKMKMLFLANLECETLCQAALLLCSWRA 579
            :....||..|..:  .|.:::..||:.:..|.:         ||:
 Worm   531 TIMANLAPHLISR--AERQLRATFLSRMNREDI---------WRS 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PINK1	NP_115785.1	STKc_PINK1	162..512	CDD:270920	130/362 (36%)
pink-1	NP_495017.1	S_TKc	137..468	CDD:214567	124/353 (35%)
		STKc_PINK1	143..483	CDD:270920	130/362 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG4158
Hieranoid	1	1.000
Homologene	1	1.000				H32672
Inparanoid	1	1.050	205	1.000	Inparanoid score	I2727
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0007807
OrthoInspector	1	1.000				T505853
orthoMCL	1	0.900				OOG5_134199
Panther	1	1.100			LDO	PTHR22972
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R2724
TreeFam	0	0.000	Not matched by this tool.
	10	9.890